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Review
. 2021 May 3;13(5):a040535.
doi: 10.1101/cshperspect.a040535.

Glycolysis

Navdeep S Chandel  1
Affiliations
Review

Glycolysis

Navdeep S Chandel. Cold Spring Harb Perspect Biol. .
No abstract available

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Figures

Figure 1.
Figure 1.
The 10 steps of glycolysis.
Figure 2.
Figure 2.
Glycolytic intermediates funnel into biosynthetic pathways.
Figure 3.
Figure 3.
Gibbs free-energy change in 10 steps of glycolysis. The free-energy changes are based on Table 1. Note that the Gibbs free-energy changes in reactions 6–10 are multiplied by 2 because one molecule of glucose is converted into two molecules of glyceraldehyde 3-phosphate.
Figure 4.
Figure 4.
Regeneration of NAD+ by LDH or mitochondria.
Figure 5.
Figure 5.
Fermentation in mammals and yeast.
Figure 6.
Figure 6.
Regulation of glycolysis by metabolites.
Figure 7.
Figure 7.
Positron-emission tomography (PET) imaging with 18fluorodeoxyglucose (FDG) of a patient with lymphoma. The mediastinal nodes (purple arrow) and supraclavicular nodes (green arrows) show high uptake of FDG, indicating that tumors in these nodes have high levels of glucose metabolism. The bladder (yellow arrow) also has high activity because of excretion of the radionuclide. (Reprinted from Gatenby and Gillies 2004, with permission from Macmillan Publishers.)
See this image and copyright information in PMC

References

    1. Bar-Even A1, Flamholz A, Noor E, Milo R. 2012. Rethinking glycolysis: on the biochemical logic of metabolic pathways. Nat Chem Biol 8: 509–517. 10.1038/nchembio.971 - DOI - PubMed
    1. Chandel NS. 2020a. Mitochondria. Cold Spring Harb Perspect Biol 10.1101/cshperspect.a040543 - DOI - PMC - PubMed
    1. Chandel NS. 2020b. Basics of metabolic reactions. Cold Spring Harb Perspect Biol 10.1101/cshperspect.a040527 - DOI - PMC - PubMed
    1. Chandel NS. 2020c. Signaling and metabolism. Cold Spring Harb Perspect Biol 10.1101/cshperspect.a040600 - DOI - PMC - PubMed
    1. Chandel NS. 2020d. Carbohydrate metabolism. Cold Spring Harb Perspect Biol 10.1101/cshperspect.a040568 - DOI - PMC - PubMed

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