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. 2021 May 3;11(5):e046980.
doi: 10.1136/bmjopen-2020-046980.

Association of frailty status with adverse clinical outcomes in patients with COVID-19: protocol for a systematic review and dose-response meta-analysis

Hanjun Pei  1 , Ying Wang  2 , Xinghui Zhang  2 , Wenlong Luo  2 , Chenghui Zhou  3
Affiliations

Association of frailty status with adverse clinical outcomes in patients with COVID-19: protocol for a systematic review and dose-response meta-analysis

Hanjun Pei et al. BMJ Open. .

Abstract

Introduction: Frailty status has been recognised as an important prognostic factor of adverse clinical outcomes in various clinical settings. Recently, the role of frailty status in adverse clinical outcomes for COVID-19-infected patients has received increasing attention with controversial results. Hence, we will conduct a comprehensive dose-response meta-analysis to quantitatively evaluate the association between frailty status and adverse clinical outcomes in patients with COVID-19.

Methods: The researchers will systematically search PubMed, EMBase, Cochrane Library, ISI Knowledge via Web of Science and MedRxiv or BioRxiv databases (from inception until December 2020) to identify all retrospective and prospective cohort studies. All-cause mortality during hospitalisation will be set as the primary outcome. Univariable or multivariable meta-regression and subgroup analyses will be conducted for the comparison between frail versus non-frail categories. Sensitivity analyses will be used to assess the robustness of our results by removing each included study one at a time to obtain and evaluate the remaining overall estimates of all-cause mortality. To conduct a dose-response meta-analysis for the potential linear or restricted cubic spline regression relationship between frailty status and all-cause mortality, studies with three or more categories will be included.

Ethics and dissemination: In accordance with the Institutional Review Board/Independent Ethics Committee of the First Affiliated Hospital of Baotou Medical College, ethical approval is not an essential element for the systematic review protocol. This meta-analysis will be disseminated through publication in a peer-reviewed journal.

Prospero registration number: CRD42020220226.

Keywords: COVID-19; adult intensive & critical care; preventive medicine.

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Conflict of interest statement

Competing interests: None declared.

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Flow chart of the trial searching process.
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References

    1. Hewitt J, Carter B, McCarthy K, et al. . Frailty predicts mortality in all emergency surgical admissions regardless of age. An observational study. Age Ageing 2019;48:388–94. 10.1093/ageing/afy217 - DOI - PubMed
    1. Cunha AIL, Veronese N, de Melo Borges S, et al. . Frailty as a predictor of adverse outcomes in hospitalized older adults: a systematic review and meta-analysis. Ageing Res Rev 2019;56:100960. 10.1016/j.arr.2019.100960 - DOI - PubMed
    1. Joseph B, Pandit V, Zangbar B, et al. . Superiority of frailty over age in predicting outcomes among geriatric trauma patients: a prospective analysis. JAMA Surg 2014;149:766–72. 10.1001/jamasurg.2014.296 - DOI - PubMed
    1. Robinson TN, Eiseman B, Wallace JI, et al. . Redefining geriatric preoperative assessment using frailty, disability and co-morbidity. Ann Surg 2009;250:449–55. 10.1097/SLA.0b013e3181b45598 - DOI - PubMed
    1. Sündermann SH, Dademasch A, Seifert B, et al. . Frailty is a predictor of short- and mid-term mortality after elective cardiac surgery independently of age. Interact Cardiovasc Thorac Surg 2014;18:580–5. 10.1093/icvts/ivu006 - DOI - PubMed

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