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. 2021 Apr 13;134(9):1055-1057.
doi: 10.1097/CM9.0000000000001455.

Co-mutations in tumor immune microenvironment and immunotherapy

Affiliations

Co-mutations in tumor immune microenvironment and immunotherapy

Ling Ma et al. Chin Med J (Engl). .
No abstract available

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Conflict of interest statement

None.

References

    1. Skoulidis F, Heymach JV. Co-occurring genomic alterations in non-small-cell lung cancer biology and therapy. Nat Rev Cancer 2019; 19:495–509. doi: 10.1038/s41568-019-0179-8. - PMC - PubMed
    1. Skoulidis F, Byers LA, Diao L, Papadimitrakopoulou VA, Tong P, Izzo J, et al. . Co-occurring genomic alterations define major subsets of KRAS-mutant lung adenocarcinoma with distinct biology, immune profiles, and therapeutic vulnerabilities. Cancer Discov 2015; 5:860–877. doi: 10.1158/2159-8290.CD-14-1236. - PMC - PubMed
    1. Arbour KC, Jordan E, Kim HR, Dienstag J, Yu HA, Sanchez-Vega F, et al. . Effects of co-occurring genomic alterations on outcomes in patients with KRAS-mutant non-small cell lung cancer. Clin Cancer Res 2018; 24:334–340. doi: 10.1158/1078-0432.CCR-17-1841. - PMC - PubMed
    1. Calles A, Sholl LM, Rodig SJ, Pelton AK, Hornick JL, Butaney M, et al. . Immunohistochemical loss of LKB1 is a biomarker for more aggressive biology in KRAS-mutant lung adenocarcinoma. Clin Cancer Res 2015; 21:2851–2860. doi: 10.1158/1078-0432.CCR-14-3112. - PubMed
    1. Koyama S, Akbay EA, Li YY, Aref AR, Skoulidis F, Herter-Sprie GS, et al. . STK11/LKB1 deficiency promotes neutrophil recruitment and proinflammatory cytokine production to suppress T-cell activity in the lung tumor microenvironment. Cancer Res 2016; 76:999–1008. doi: 10.1158/0008-5472.CAN-15-1439. - PMC - PubMed

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