Accelerated Skin Wound Healing by Electrical Stimulation

doi:10.1002/adhm.202100557

Review

. 2021 Aug;10(16):e2100557.

doi: 10.1002/adhm.202100557. Epub 2021 May 4.

Accelerated Skin Wound Healing by Electrical Stimulation

Ruizeng Luo¹, Jieyu Dai¹, Jiaping Zhang², Zhou Li^{1

3

4}

Affiliations

¹ College of Chemistry and Chemical Engineering, Center of Nanoenergy Research, Guangxi University, Nanning, 530004, China.
² Department of Plastic Surgery, State Key Laboratory of Trauma, Burns and Combined Injury, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, 400038, China.
³ CAS Center for Excellence in Nanoscience, Beijing Key Laboratory of Micro-Nano Energy and Sensor, Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences, Beijing, 100083, China.
⁴ School of Nanoscience and Technology, University of Chinese Academy of Sciences, Beijing, 100049, China.

PMID: 33945225
DOI: 10.1002/adhm.202100557

Review

Accelerated Skin Wound Healing by Electrical Stimulation

Ruizeng Luo et al. Adv Healthc Mater. 2021 Aug.

. 2021 Aug;10(16):e2100557.

doi: 10.1002/adhm.202100557. Epub 2021 May 4.

Authors

Ruizeng Luo¹, Jieyu Dai¹, Jiaping Zhang², Zhou Li^{1

3

4}

Affiliations

¹ College of Chemistry and Chemical Engineering, Center of Nanoenergy Research, Guangxi University, Nanning, 530004, China.
² Department of Plastic Surgery, State Key Laboratory of Trauma, Burns and Combined Injury, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, 400038, China.
³ CAS Center for Excellence in Nanoscience, Beijing Key Laboratory of Micro-Nano Energy and Sensor, Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences, Beijing, 100083, China.
⁴ School of Nanoscience and Technology, University of Chinese Academy of Sciences, Beijing, 100049, China.

PMID: 33945225
DOI: 10.1002/adhm.202100557

Abstract

When the integrity of the skin got damaged, an endogenous electric field will be generated in the wound and a series of physiological reactions will be initiated to close the wound. The existence of the endogenous electric field of the wound has a promoting effect on all stages of wound healing. For wounds that cannot heal on their own, the exogenous electric field can assist the treatment. In this review, the effects of exogenous electrical stimulation on wound healing, such as the inflammation phase, blood flow, cell proliferation and migration, and the wound scarring is overviewed. This article also reviews the new electrical stimulation methods that have emerged in recent years, such as small power supplies, nanogenerators (NGs), and other physical, chemical or biological strategies. These new electrical stimulation methods and devices are safe, low-cost, stable, and small in size. The challenge and perspective are discussed for the future trends of the electrical stimulation treatment in accelerating skin wound healing.

Keywords: accelerated healing; endogenous electric fields; exogenous electrical stimulation; nanogenerators; wounds.

PubMed Disclaimer

Cited by

Endogenous electric field coupling Mxene sponge for diabetic wound management: haemostatic, antibacterial, and healing.
Zhou H, Chen L, Huang C, Jiang Z, Zhang H, Liu X, Zhu F, Wen Q, Shi P, Liu K, Yang L. Zhou H, et al. J Nanobiotechnology. 2024 Sep 2;22(1):530. doi: 10.1186/s12951-024-02799-5. J Nanobiotechnology. 2024. PMID: 39218901 Free PMC article.
A carbon nanotube/pyrrolidonecarboxylic acid zinc sponge for programmed management of diabetic wounds: Hemostatic, antibacterial, anti-inflammatory, and healing properties.
Wu C, Liu B, Wen Q, Zhai Q. Wu C, et al. Mater Today Bio. 2025 Apr 12;32:101769. doi: 10.1016/j.mtbio.2025.101769. eCollection 2025 Jun. Mater Today Bio. 2025. PMID: 40290885 Free PMC article.
LIPUS Responsive Dopamine-Modified PVDF Piezoelectric Nanofiber Membrane for Full-Thickness Skin Wound Healing.
Zhang Z, Liu L, Wang H, Xie W, Zhai W, Wen L, Zhang B, Liu K, Zhang X, Liu S, Huang L, Li D, Zhou Y. Zhang Z, et al. Int J Nanomedicine. 2025 May 1;20:5693-5707. doi: 10.2147/IJN.S496921. eCollection 2025. Int J Nanomedicine. 2025. PMID: 40331232 Free PMC article.
MXenes in the application of diabetic foot: mechanisms, therapeutic implications and future perspectives.
Mengru Z, Qinyi W, Zimo Y, Bingqing G, Zhongyu X, Xu J. Mengru Z, et al. J Mater Sci Mater Med. 2025 May 15;36(1):42. doi: 10.1007/s10856-025-06895-2. J Mater Sci Mater Med. 2025. PMID: 40374863 Free PMC article. Review.
Optimizing Flexible Microelectrode Designs for Enhanced Efficacy in Electrical Stimulation Therapy.
Qi L, Tao Z, Liu M, Yao K, Song J, Shang Y, Su D, Liu N, Jiang Y, Wang Y. Qi L, et al. Micromachines (Basel). 2024 Aug 30;15(9):1104. doi: 10.3390/mi15091104. Micromachines (Basel). 2024. PMID: 39337764 Free PMC article.

See all "Cited by" articles

References

1. M. C. Robson, D. L. Steed, M. G. Franz, Curr. Probl. Surg. 2001, 38, 387.
1. T. Velnar, T. Bailey, V. Smrkoli, J. Int. Med. Res. 2009, 37, 1528.
1. P. Martin, Science 1997, 276, 75.
1. a) A. V. Singh, D. Gemmati, A. Kanase, I. Pandey, V. Misra, V. Kishore, T. Jahnke, J. Bill, Veins Lymphatics 2018, 7, 7196;
1. b) C. Dwivedi, H. Pandey, A. C. Pandey, S. Patil, P. W. Ramteke, P. Laux, A. Luch, A. V. Singh, Pharmaceutics 2019, 11, 180.

Publication types

Actions
Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions

LinkOut - more resources

Full Text Sources
- Ovid Technologies, Inc.
- Wiley
Other Literature Sources
- scite Smart Citations

[1] M. C. Robson, D. L. Steed, M. G. Franz, Curr. Probl. Surg. 2001, 38, 387.

[2] M. C. Robson, D. L. Steed, M. G. Franz, Curr. Probl. Surg. 2001, 38, 387.

[3] T. Velnar, T. Bailey, V. Smrkoli, J. Int. Med. Res. 2009, 37, 1528.

[4] T. Velnar, T. Bailey, V. Smrkoli, J. Int. Med. Res. 2009, 37, 1528.

[5] P. Martin, Science 1997, 276, 75.

[6] P. Martin, Science 1997, 276, 75.

[7] a) A. V. Singh, D. Gemmati, A. Kanase, I. Pandey, V. Misra, V. Kishore, T. Jahnke, J. Bill, Veins Lymphatics 2018, 7, 7196;

[8] a) A. V. Singh, D. Gemmati, A. Kanase, I. Pandey, V. Misra, V. Kishore, T. Jahnke, J. Bill, Veins Lymphatics 2018, 7, 7196;

[9] b) C. Dwivedi, H. Pandey, A. C. Pandey, S. Patil, P. W. Ramteke, P. Laux, A. Luch, A. V. Singh, Pharmaceutics 2019, 11, 180.

[10] b) C. Dwivedi, H. Pandey, A. C. Pandey, S. Patil, P. W. Ramteke, P. Laux, A. Luch, A. V. Singh, Pharmaceutics 2019, 11, 180.

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Accelerated Skin Wound Healing by Electrical Stimulation

Affiliations

Accelerated Skin Wound Healing by Electrical Stimulation

Authors

Affiliations

Abstract

Similar articles

Cited by

References

Publication types

MeSH terms

LinkOut - more resources

Full Text Sources

Other Literature Sources

Abstract

Similar articles

Cited by

References

Publication types

MeSH terms

Related information

LinkOut - more resources

Full Text Sources

Other Literature Sources