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Case Reports
. 2021 Jul 1;137(26):3670-3673.
doi: 10.1182/blood.2021011548.

COVID-19 vaccines induce severe hemolysis in paroxysmal nocturnal hemoglobinuria

Gloria F Gerber  1 , Xuan Yuan  1 , Jia Yu  1 , Benjamin A Y Cher  2 , Evan M Braunstein  1 , Shruti Chaturvedi  1 , Robert A Brodsky  1
Affiliations
Case Reports

COVID-19 vaccines induce severe hemolysis in paroxysmal nocturnal hemoglobinuria

Gloria F Gerber et al. Blood. .
No abstract available

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Figures

Figure 1.
Figure 1.
Erythrocyte lysis with addition of the SARS-CoV-2 spike protein S1. Hemolysis is not increased with addition of the SARS-CoV-2 spike protein S1 to PNH erythrocytes. Addition of 40% aNHS with various concentrations of the spike protein to type O-positive erythrocytes from a patient with PNH (49% PNH red blood cell clone: 25% type III and 24% type II cells) and type O-positive erythrocytes from a healthy control, incubated at 37°C for 1 hour. Water (H2O) serves as a positive control. EDTA added to serum serves as an inhibitor of hemolysis. Data are shown as mean ± standard error of the mean of duplicate wells.
See this image and copyright information in PMC

References

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