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Meta-Analysis
. 2021 Apr 30;22(9):4798.
doi: 10.3390/ijms22094798.

Impact of Obesity-Induced Inflammation on Cardiovascular Diseases (CVD)

Gopi Battineni  1 , Getu Gamo Sagaro  1 , Nalini Chintalapudi  1 , Francesco Amenta  1   2 , Daniele Tomassoni  3 , Seyed Khosrow Tayebati  1   2
Affiliations
Meta-Analysis

Impact of Obesity-Induced Inflammation on Cardiovascular Diseases (CVD)

Gopi Battineni et al. Int J Mol Sci. .

Abstract

Overweight and obesity are key risk factors of cardiovascular disease (CVD). Obesity is currently presented as a pro-inflammatory state with an expansion in the outflow of inflammatory cytokines, such as interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α), alongside the expanded emission of leptin. The present review aimed to evaluate the relationship between obesity and inflammation and their impacts on the development of cardiovascular disease. A literature search was conducted by employing three academic databases, namely PubMed (Medline), Scopus (EMBASE), and the Cumulative Index to Nursing and Allied Health Literature (CINAHL). The search presented 786 items, and by inclusion and exclusion filterers, 59 works were considered for final review. The Newcastle-Ottawa Scale (NOS) method was adopted to conduct quality assessment; 19 papers were further selected based on the quality score. Obesity-related inflammation leads to a low-grade inflammatory state in organisms by upregulating pro-inflammatory markers and downregulating anti-inflammatory cytokines, thereby contributing to cardiovascular disease pathogenesis. Because of inflammatory and infectious symptoms, adipocytes appear to instigate articulation and discharge a few intense stage reactants and carriers of inflammation. Obesity and inflammatory markers are strongly associated, and are important factors in the development of CVD. Hence, weight management can help prevent cardiovascular risks and poor outcomes by inhibiting inflammatory mechanisms.

Keywords: cardiovascular diseases; inflammation; inflammatory cytokines; metabolic syndrome; obesity.

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Conflict of interest statement

No authors have any conflicts of interest during the publication of the manuscript.

Figures

Figure 1
Figure 1
The study selection flow chart.
Figure 2
Figure 2
Cardiovascular disease (CVD) is related to inflammatory processes in obesity; modified from Mathieu et al., 2010 [49].
Figure 3
Figure 3
Pharmacological and non-pharmacological interventions to prevent CVD complications in obesity. Peroxisome proliferator-activated receptor gamma (PPAR-γ); non-steroidal anti-inflammatory drugs (NSAIDs).
See this image and copyright information in PMC

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