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. 2021 Apr 30;10(9):1940.
doi: 10.3390/jcm10091940.

Association of Immune Thrombocytopenia and Inflammatory Bowel Disease in Children

Angela Guarina  1 , Angelica Barone  2 , Assunta Tornesello  3 , Maddalena Marinoni  4 , Giuseppe Lassandro  5 , Paola Giordano  5 , Milena Motta  6 , Marco Spinelli  7 , Ilaria Fontanili  2 , Fiorina Giona  8 , Francesco Menna  9 , Elena Chiocca  10 , Ilaria Fotzi  10 , Angelamaria Petrone  11 , Francesco Graziano  12 , Paola Saracco  13 , Giuseppe Puccio  1 , Michele Citrano  12 , Giovanna Russo  6 , Piero Farruggia  1
Affiliations

Association of Immune Thrombocytopenia and Inflammatory Bowel Disease in Children

Angela Guarina et al. J Clin Med. .

Abstract

Background: The association between inflammatory bowel disease (IBD) and immune thrombocytopenia (ITP) is still uncertain. In this multicenter retrospective study, the coexistence of both diseases was investigated in children diagnosed from 1 January 2000 to 31 December 2019.

Methods: Clinical characteristics of both IBD and ITP, onset of disorders, and patient's response to treatment were collected through a structured form sent to 55 Italian pediatric referring centers for hematological disorders.

Result: Centers responded to the survey and reported the coexistence of IBD and ITP in 14 children. The first diagnosis was ITP in 57.1% and IBD in 35.7% of patients: it was simultaneous in 7.1%. IBD was classified as ulcerative colitis (57.1%), Crohn disease (35.7%), and unclassified (7.1%). No therapy for IBD other than steroids had any effect on ITP course. Colectomy resulted in recovery from ITP in 1 of the 2 patients surgically treated. ITP was always mild but turned to be chronic in half of patients.

Conclusions: In all patients, ITP was mild without any evident impact on IBD severity, but the incidence of chronic ITP seems to be higher than what is usually observed in the pediatric age group. Colectomy had unpredictable effects on ITP.

Keywords: bowel; children; immune; pediatric; thrombocytopenia.

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Conflict of interest statement

The authors declare no conflict of interest.

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