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Review
. 2021 Apr 29;22(9):4697.
doi: 10.3390/ijms22094697.

Role of miRNA-19a in Cancer Diagnosis and Poor Prognosis

Alessio Ardizzone  1 , Giovanna Calabrese  1 , Michela Campolo  1 , Alessia Filippone  1 , Dario Giuffrida  2 , Francesca Esposito  3 , Cristina Colarossi  2 , Salvatore Cuzzocrea  1 , Emanuela Esposito  1 , Irene Paterniti  1
Affiliations
Review

Role of miRNA-19a in Cancer Diagnosis and Poor Prognosis

Alessio Ardizzone et al. Int J Mol Sci. .

Abstract

Cancer is a multifactorial disease that affects millions of people every year and is one of the most common causes of death in the world. The high mortality rate is very often linked to late diagnosis; in fact, nowadays there are a lack of efficient and specific markers for the early diagnosis and prognosis of cancer. In recent years, the discovery of new diagnostic markers, including microRNAs (miRNAs), has been an important turning point for cancer research. miRNAs are small, endogenous, non-coding RNAs that regulate gene expression. Compelling evidence has showed that many miRNAs are aberrantly expressed in human carcinomas and can act with either tumor-promoting or tumor-suppressing functions. miR-19a is one of the most investigated miRNAs, whose dysregulated expression is involved in different types of tumors and has been potentially associated with the prognosis of cancer patients. The aim of this review is to investigate the role of miR-19a in cancer, highlighting its involvement in cell proliferation, cell growth, cell death, tissue invasion and migration, as well as in angiogenesis. On these bases, miR-19a could prove to be truly useful as a potential diagnostic, prognostic, and therapeutic marker.

Keywords: cancer; diagnostic and prognostic markers; miR-19a; miR-19a therapeutic value; miRNAs; oncogene; poor prognosis; tumor suppressors.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
miR-19a and its main target genes. The figure summarizes the interactions between miR-19a and the target genes on which it acts, also indicating each their main biological effects.
Figure 2
Figure 2
Promising clinical values of miR-19a for early cancer diagnosis, treatment, and prognosis.
See this image and copyright information in PMC

References

    1. Sun W., Shi Q., Zhang H., Yang K., Ke Y., Wang Y., Qiao L. Advances in the techniques and methodologies of cancer gene therapy. Discov. Med. 2019;27:45–55. - PubMed
    1. Roma-Rodrigues C., Mendes R., Baptista P.V., Fernandes A.R. Targeting Tumor Microenvironment for Cancer Therapy. Int. J. Mol. Sci. 2019;20:840. doi: 10.3390/ijms20040840. - DOI - PMC - PubMed
    1. Lewandowska A.M., Rudzki M., Rudzki S., Lewandowski T., Laskowska B. Environmental risk factors for cancer—Review paper. Ann. Agric. Environ. Med. 2019;26:1–7. doi: 10.26444/aaem/94299. - DOI - PubMed
    1. Samet J.M. Tobacco Smoking. Thorac. Surg. Clin. 2013;23:103–112. doi: 10.1016/j.thorsurg.2013.01.009. - DOI - PubMed
    1. Miller M., Bailey B., Govindarajah V., Levin L., Metzger T., Pinney S.M., Leung Y.-K., Ho S.-M. A community survey on knowledge of the impact of environmental and epigenetic factors on health and disease. Perspect. Public Health. 2016;136:345–352. doi: 10.1177/1757913916630341. - DOI - PMC - PubMed

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