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. 2021 May;49(5):3000605211012596.
doi: 10.1177/03000605211012596.

Outcomes of late Kasai portoenterostomy in biliary atresia: a single-center experience

Ammar Khayat  1   2 , Aisha M Alamri  3 , Omar I Saadah  2   4
Affiliations

Outcomes of late Kasai portoenterostomy in biliary atresia: a single-center experience

Ammar Khayat et al. J Int Med Res. 2021 May.

Abstract

Objectives: To describe the clinical, histopathologic, and outcomes data for a cohort of patients with biliary atresia (BA), and to identify the factors affecting survival.

Methods: This was a cross-sectional study of all BA patients diagnosed between 1999 and 2017. Clinical, biochemical, imaging, and histopathologic data were analyzed, and Kaplan-Meier survival rates were compared to identify potential prognostic factors.

Results: We evaluated 23 patients. The median age at the Kasai procedure was 77 ± 34 days, and the median overall survival was 12.5 ± 65 months. Thirteen (56%) patients survived with their native livers, 3 (13%) received a transplant, and 6 died (26%) while awaiting a transplant. Cholangitis and the use of ursodeoxycholic acid were associated with longer survival, while impaired synthetic function was associated with shorter survival.

Conclusions: Most patients presented late for the Kasai procedure. The survival rate with the native liver was comparable to other cohorts. Therefore, clinicians are encouraged to refer for the Kasai procedure even with late presentation (between 60 and 90 days), provided there is no hepatic decompensation.

Keywords: Kasai portoenterostomy; Saudi Arabia; biliary atresia; cholestasis; liver transplantation; pediatric.

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Conflict of interest statement

Declaration of conflicting interest: The authors declare that there is no conflict of interest.

Figures

Figure 1.
Figure 1.
Kaplan–Meier survival plot showing the mean survival of patients (n = 18) who received ursodeoxycholic acid (solid line) and those who did not (dashed line).
Figure 2.
Figure 2.
Kaplan–Meier survival plot showing the mean survival of patients (n = 20) with cholangitis (solid line) and those without (dashed line).
Figure 3.
Figure 3.
Kaplan–Meier survival plot showing the mean survival of patients (n = 20) who had impaired synthetic function (dashed line) and those with normal synthetic function (solid line).
Figure 4.
Figure 4.
Kaplan–Meier survival plot showing the mean survival of patients (n = 19) with liver failure post-Kasai (dashed line) and those without (solid line)
See this image and copyright information in PMC

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