Effects of non-pharmacological and non-surgical interventions on health outcomes in systemic sclerosis: protocol for a living systematic review

Marie-Nicole Discepola^{1

2}, Andrea Carboni-Jiménez^{1

3}, Linda Kwakkenbos⁴, Richard S Henry^{1

3}, Jill Boruff⁵, Ankur Krishnan¹, Carina Boström⁶, S Nicole Culos-Reed⁷, Marie Hudson⁸, David M Leader⁹, Malin Mattsson^{6

10}, Luc Mouthon^{11

12}, Robyn Wojeck¹³, Elizabeth Yakes Jimenez¹⁴, Maureen Sauve¹⁵, Joep Welling¹⁶, Geneviève Guillot¹⁷, Andrea Benedetti^{8

18

19

20}, Brett D Thombs^{21

3

8

18

22

23}

Affiliations

¹ Lady Davis Institute of the Jewish General Hospital, Montreal, Quebec, Canada.
² Department of Psychology, McGill University, Montreal, Quebec, Canada.
³ Department of Psychiatry, McGill University, Montreal, Quebec, Canada.
⁴ Department of Clinical Psychology, Behavioural Science Institute, Radboud Universiteit, Nijmegen, The Netherlands.
⁵ Schulich Library of Physical Sciences, Life Sciences, and Engineering, McGill University, Montreal, Quebec, Canada.
⁶ Department of Neurobiology, Care Sciences and Society, Division of Physiotherapy, Karolinska Institutet, Stockholm, Sweden.
⁷ Faculty of Kinesiology, University of Calgary, Calgary, Alberta, Canada.
⁸ Department of Medicine, McGill University Faculty of Medicine, Montreal, Quebec, Canada.
⁹ Tufts University School of Dental Medicine, Boston, Massachusetts, USA.
¹⁰ Department of Physiotherapy, Sunderby Hospital, Lulea, Sweden.
¹¹ Service de Médecine Interne, Centre de Référence Maladies Auto-immunes et Systémiques Rares d'Ile de France, Hopital Cochin Assistance Publique - Hôpitaux de Paris (APHP), Paris, France.
¹² APHP-CUP, Hôpital Cochin, Université de Paris, Paris, France.
¹³ School of Nursing, Duke University, Durham, North Carolina, USA.
¹⁴ Departments of Pediatrics and Internal Medicine and College of Population Health, University of New Mexico, Albuquerque, California, USA.
¹⁵ Scleroderma Societies of Canada and Ontario, Hamilton, Ontario, Canada.
¹⁶ FESCA Patient Research Partner, Utrecht, The Netherlands.
¹⁷ Sclérodermie Québec, Montreal, Quebec, Canada.
¹⁸ Departments of Medicine and of Epidemiology, Biostatistics & Occupational Health, McGill University, Montreal, Quebec, Canada.
¹⁹ Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada, Montreal, Quebec, Canada.
²⁰ Respiratory Epidemiology and Clinical Research Unit, McGill University Health Centre, Montreal, Quebec, Canada.
²¹ Lady Davis Institute of the Jewish General Hospital, Montreal, Quebec, Canada brett.thombs@mcgill.ca.
²² Department of Educational and Counselling Psychology, McGill University, Montreal, Quebec, Canada.
²³ Biomedical Ethics Unit, McGill University, Montreal, Quebec, Canada.

PMID: 33947738
PMCID: PMC8098987
DOI: 10.1136/bmjopen-2020-047428

Effects of non-pharmacological and non-surgical interventions on health outcomes in systemic sclerosis: protocol for a living systematic review

Marie-Nicole Discepola et al. BMJ Open. 2021.

. 2021 May 4;11(5):e047428.

doi: 10.1136/bmjopen-2020-047428.

Authors

Affiliations

¹ Lady Davis Institute of the Jewish General Hospital, Montreal, Quebec, Canada.
² Department of Psychology, McGill University, Montreal, Quebec, Canada.
³ Department of Psychiatry, McGill University, Montreal, Quebec, Canada.
⁴ Department of Clinical Psychology, Behavioural Science Institute, Radboud Universiteit, Nijmegen, The Netherlands.
⁵ Schulich Library of Physical Sciences, Life Sciences, and Engineering, McGill University, Montreal, Quebec, Canada.
⁶ Department of Neurobiology, Care Sciences and Society, Division of Physiotherapy, Karolinska Institutet, Stockholm, Sweden.
⁷ Faculty of Kinesiology, University of Calgary, Calgary, Alberta, Canada.
⁸ Department of Medicine, McGill University Faculty of Medicine, Montreal, Quebec, Canada.
⁹ Tufts University School of Dental Medicine, Boston, Massachusetts, USA.
¹⁰ Department of Physiotherapy, Sunderby Hospital, Lulea, Sweden.
¹¹ Service de Médecine Interne, Centre de Référence Maladies Auto-immunes et Systémiques Rares d'Ile de France, Hopital Cochin Assistance Publique - Hôpitaux de Paris (APHP), Paris, France.
¹² APHP-CUP, Hôpital Cochin, Université de Paris, Paris, France.
¹³ School of Nursing, Duke University, Durham, North Carolina, USA.
¹⁴ Departments of Pediatrics and Internal Medicine and College of Population Health, University of New Mexico, Albuquerque, California, USA.
¹⁵ Scleroderma Societies of Canada and Ontario, Hamilton, Ontario, Canada.
¹⁶ FESCA Patient Research Partner, Utrecht, The Netherlands.
¹⁷ Sclérodermie Québec, Montreal, Quebec, Canada.
¹⁸ Departments of Medicine and of Epidemiology, Biostatistics & Occupational Health, McGill University, Montreal, Quebec, Canada.
¹⁹ Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada, Montreal, Quebec, Canada.
²⁰ Respiratory Epidemiology and Clinical Research Unit, McGill University Health Centre, Montreal, Quebec, Canada.
²¹ Lady Davis Institute of the Jewish General Hospital, Montreal, Quebec, Canada brett.thombs@mcgill.ca.
²² Department of Educational and Counselling Psychology, McGill University, Montreal, Quebec, Canada.
²³ Biomedical Ethics Unit, McGill University, Montreal, Quebec, Canada.

PMID: 33947738
PMCID: PMC8098987
DOI: 10.1136/bmjopen-2020-047428

Abstract

Introduction: Systemic sclerosis (SSc; scleroderma) is a rare, chronic, autoimmune disease with a high level of burden, a significant impact on the ability to carry out daily activities, and a considerable negative impact on health-related quality of life. Non-pharmacological interventions could be provided to potentially improve mental and physical health outcomes. However, the effectiveness of non-pharmacological interventions on health and well-being among individuals with SSc has not been well established. The proposed living systematic review aims to identify and evaluate randomised controlled trial (RCT) evidence on the effectiveness of non-pharmacological and non-surgical interventions on mental and physical health outcomes and on the delivery of such services in SSc.

Methods and analysis: Eligible studies will be RCTs that examine non-pharmacological and non-surgical interventions aimed at improving health outcomes among individuals with SSc or the delivery of services intended to improve healthcare or support of people with SSc (eg, support groups). All RCTs included in a previous systematic review that sought studies published between 1990 and March 2014 will be evaluated for inclusion. Additional trials will be sought from January 2014 onwards using a similar, augmented search strategy developed by a health sciences librarian. We will search the MEDLINE, Embase, CINAHL, PsycINFO, Cochrane Library and Web of Science databases and will not restrict by language. Two independent reviewers will determine the eligibility of identified RCTs and will extract data using a prespecified standardised form in DistillerSR. Meta-analyses will be considered if ≥2 eligible RCTs report similar non-pharmacological interventions and comparable health outcomes. We will conduct a qualitative synthesis for interventions that cannot be synthesised via meta-analysis.

Ethics and dissemination: We will post initial and ongoing results via a website, publish results periodically via peer-reviewed journal publication, and present results at patient-oriented events.

Prospero registration number: CRD42020219914.

Keywords: health services administration & management; immunology; rheumatology.

PubMed Disclaimer

Conflict of interest statement

Competing interests: None declared.

References

1. Mayes MD. Systemic sclerosis: clinical features. : Klippel JH, Stone JH, White PH, . Primer on the rheumatic diseases. New York, NY: Springer Science & Business Media, 2008: 343–50.
1. Gelber AC, Manno RL, Shah AA, et al. Race and association with disease manifestations and mortality in scleroderma: a 20-year experience at the Johns Hopkins scleroderma center and review of the literature. Medicine 2013;92:191–205. 10.1097/MD.0b013e31829be125 - DOI - PMC - PubMed
1. Kwakkenbos L, Delisle VC, Fox RS, et al. Psychosocial aspects of scleroderma. Rheum Dis Clin North Am 2015;41:519–28. 10.1016/j.rdc.2015.04.010 - DOI - PubMed
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1. Bassel M, Hudson M, Taillefer SS, et al. Frequency and impact of symptoms experienced by patients with systemic sclerosis: results from a Canadian national survey. Rheumatology 2011;50:762–7. 10.1093/rheumatology/keq310 - DOI - PubMed

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Effects of non-pharmacological and non-surgical interventions on health outcomes in systemic sclerosis: protocol for a living systematic review

Affiliations

Effects of non-pharmacological and non-surgical interventions on health outcomes in systemic sclerosis: protocol for a living systematic review

Authors

Affiliations

Abstract

Conflict of interest statement

References

Publication types

MeSH terms

LinkOut - more resources

Full Text Sources

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Medical