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Comment
. 2021 Jul;31(7):725-726.
doi: 10.1038/s41422-021-00511-y.

Ultrasensitive antigen density discrimination by synNotch

Divanshu Shukla  1 , James L Riley  2
Affiliations
Comment

Ultrasensitive antigen density discrimination by synNotch

Divanshu Shukla et al. Cell Res. 2021 Jul.
No abstract available

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Conflict of interest statement

J.L.R. is a co-founder and shareholder of Tmunity Therapeutics. He has been in receipt of research funding from Tmunity Therapeutics. D.S. declares no competing interests.

Figures

Fig. 1
Fig. 1. Overview of synNotch CAR that becomes active only in the presence of high levels of antigen.
a Based on the results shown by Hernandez-Lopez et al., constitutive CAR T cells expressing either low- or high-affinity CARs rapidly killed low (left) as well as high (right) antigen target cells, showing poor density discrimination. b Upon the interaction of low antigen density target, low-affinity synNotch receptors suppress the expression of CAR (left). Conversely, in the presence of high antigen density target, synNotch receptor enhances the expression of CAR and the T-cell activity is dominated by the high-affinity CAR response to eliminate the tumor cells and minimize on-target, off-tumor toxicities (right), showing an ultrasensitive antigen density response. Illustration was made in ©BioRender — biorender.com.
See this image and copyright information in PMC

Comment on

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