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Comment
. 2021 Jun;18(6):371-372.
doi: 10.1038/s41575-021-00459-9.

Applications of organoids in regenerative medicine: a proof-of-concept for biliary injury

Pedro M Rodrigues  1   2 , Jesus M Banales  3   4   5
Affiliations
Comment

Applications of organoids in regenerative medicine: a proof-of-concept for biliary injury

Pedro M Rodrigues et al. Nat Rev Gastroenterol Hepatol. 2021 Jun.
No abstract available

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Comment on

  • Cholangiocyte organoids can repair bile ducts after transplantation in the human liver.
    Sampaziotis F, Muraro D, Tysoe OC, Sawiak S, Beach TE, Godfrey EM, Upponi SS, Brevini T, Wesley BT, Garcia-Bernardo J, Mahbubani K, Canu G, Gieseck R 3rd, Berntsen NL, Mulcahy VL, Crick K, Fear C, Robinson S, Swift L, Gambardella L, Bargehr J, Ortmann D, Brown SE, Osnato A, Murphy MP, Corbett G, Gelson WTH, Mells GF, Humphreys P, Davies SE, Amin I, Gibbs P, Sinha S, Teichmann SA, Butler AJ, See TC, Melum E, Watson CJE, Saeb-Parsy K, Vallier L. Sampaziotis F, et al. Science. 2021 Feb 19;371(6531):839-846. doi: 10.1126/science.aaz6964. Science. 2021. PMID: 33602855 Free PMC article.

References

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    1. Banales, J. M. et al. Hepatic cystogenesis is associated with abnormal expression and location of ion transporters and water channels in an animal model of autosomal recessive polycystic kidney disease. Am. J. Pathol. 173, 1637–1646 (2008). - DOI
    1. Sato, T. et al. Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche. Nature 459, 262–265 (2009). - DOI
    1. Sampaziotis, F. et al. Reconstruction of the mouse extrahepatic biliary tree using primary human extrahepatic cholangiocyte organoids. Nat. Med. 23, 954–963 (2017). - DOI
    1. Huch, M. et al. Long-term culture of genome-stable bipotent stem cells from adult human liver. Cell 160, 299–312 (2015). - DOI

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