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. 2021 Apr 8:12:144.
doi: 10.25259/SNI_25_2021. eCollection 2021.

Outcomes of infratentorial cranial surgery for tumor resection in older patients: An analysis of the National Surgical Quality Improvement Program

Krissia M Rivera Perla  1 , Nathan J Pertsch  1 , Owen P Leary  1 , Catherine M Garcia  1 , Oliver Y Tang  1 , Steven A Toms  2 , Robert J Weil  3
Affiliations

Outcomes of infratentorial cranial surgery for tumor resection in older patients: An analysis of the National Surgical Quality Improvement Program

Krissia M Rivera Perla et al. Surg Neurol Int. .

Abstract

Background: Poorer outcomes for infratentorial tumor resection have been reported. There is a lack of large multicenter analyses describing infratentorial surgery outcomes in older patients. We characterized outcomes in patients aged ≥65 years undergoing infratentorial cranial surgery.

Methods: The National Surgical Quality Improvement Project database was queried from 2012 to 2018 for patients ≥18 years undergoing elective infratentorial cranial surgery for tumor resection. Patients were grouped into 65-74 years, ≥75 years, and 18-64 years cohorts. Multivariable regressions compared outcome measures.

Results: Of 2212 patients, 28.3% were ≥65 years, of whom 24.8% were ≥75 years. Both older subpopulations had worse American Society of Anesthesiologists classification compared to controls (P < 0.01) and more comorbidities. Patients 65-74 and ≥75 years had higher rates of major complication (adjusted odds ratio [aOR] = 1.77, 95% CI = 1.13-2.79 and aOR = 3.44, 95% CI = 1.96-6.02, respectively), prolonged length of stay (LOS) (aOR = 1.89, 95% CI = 1.15-3.12 and aOR = 3.00, 95% CI = 1.65-5.44, respectively), and were more likely to be discharged to a location other than home (aOR = 2.43, 95% CI =1.73-3.4 and aOR = 3.41, 95% CI = 2.18-5.33, respectively) relative to controls. Patients ≥75 had higher rates of readmission (aOR = 1.86, 95% CI = 1.13-3.08) and mortality (aOR = 3.28, 95% CI = 1.21-8.89) at 30 days.

Conclusion: Patients ≥65 years experienced more complications, prolonged LOS, and were less often discharged home than adults <65 years. Patients ≥75 years had higher rates of 30-day readmission and mortality. There is a need for careful preoperative optimization in older patients undergoing infratentorial tumor cranial surgery.

Keywords: Brain tumor; Cranial; Elderly; Infratentorial; Meningioma.

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Conflict of interest statement

There are no conflicts of interest.

Figures

Figure 1:
Figure 1:
Population selection (age in years).
Figure 2:
Figure 2:
Infratentorial tumor type distribution by age *Age, in years, at index surgery.
Figure 3:
Figure 3:
Infratentorial 30-day mortality by age from 2012-2018. *Age, in years, at index surgery.
See this image and copyright information in PMC

References

    1. Adams H, Chaichana KL, Avendaño J, Liu B, Raza SM, Quiñones-Hinojosa A. Adult cerebellar glioblastoma: Understanding survival and prognostic factors using a population-based database from 1973 to 2009. World Neurosurg. 2013;80:e237–43. - PMC - PubMed
    1. Angarita FA, Acuna SA, Cordeiro E, Elnahas A, Sutradhar S, Jackson T, et al. Thirty-day postoperative morbidity and mortality in elderly women with breast cancer: An analysis of the NSQIP database. Breast Cancer Res Treat. 2018;170:373–9. - PubMed
    1. Babu R, Sharma R, Karikari IO, Owens TR, Friedman AH, Adamson C. Outcome and prognostic factors in adult cerebellar glioblastoma. J Clin Neurosci. 2013;20:1117–21. - PubMed
    1. Bauman G, Fisher B, Watling C, Cairncross JG, Macdonald D. Adult supratentorial low-grade glioma: Long-term experience at a single institution. Int J Radiat Oncol Biol Phys. 2009;75:1401–7. - PubMed
    1. Bondy ML, Scheurer ME, Malmer B, Barnholtz-Sloan JS, Davis FG, Il’yasova D, et al. Consensus from the brain tumor epidemiology consortium on behalf of the brain tumor epidemiology consortium. Cancer. 2008;113(Suppl 7):1953–68. - PMC - PubMed

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