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. 2022 Jun;9(3):1012-1023.
doi: 10.1007/s40615-021-01040-5. Epub 2021 May 4.

Association of Childhood Socioeconomic Status with Leukocyte Telomere Length Among African Americans and the Mediating Role of Behavioral and Psychosocial Factors: Results from the GENE-FORECAST Study

Rumana J Khan  1 , Belinda L Needham  2 , Shailesh Advani  3 , Kristen Brown  3 , Casey Dagnall  4 , Ruihua Xu  3 , Gary H Gibbons  5   6 , Sharon K Davis  3
Affiliations

Association of Childhood Socioeconomic Status with Leukocyte Telomere Length Among African Americans and the Mediating Role of Behavioral and Psychosocial Factors: Results from the GENE-FORECAST Study

Rumana J Khan et al. J Racial Ethn Health Disparities. 2022 Jun.

Abstract

Purpose: We examined if childhood socioeconomic status (SES) was related to adult leucocyte telomere length (TL) using the data of 361 African American (AA) participants from the GENE-FORECAST Study. We also assessed the mediating role of behavioral and psychosocial factors in the association between childhood SES and adult TL.

Methods: Childhood SES was assessed individually by using participant's mother's education and occupation, father's education and occupation, parental home ownership, and family structure. TL was assessed using the quantitative polymerase chain reaction method. Information on potential confounders and mediators were collected. The associations of childhood SES with TL were assessed using multivariable linear regression models. We used path analysis to quantify and test the share of these associations that was statistically explained by each of the mediators (participant's educational attainment, smoking status, physical activity, dietary habit, perceived stress, and depressive symptoms).

Results: Mother's education was associated with longer average TL (β: 0.021; 95% CI: 0.001, 0.04, p=0.038) in confounder adjusted models. Once mediators were introduced in the model, the estimates were reduced and remained marginally significant (β: 0.017; 95% CI: -0.003, 0.038, p=0.061). According to path model, approximately 19% of the effect of mother's education on TL (β: 0.004; 95% CI: -0.001, 0.01, p < 0.10) was mediated through participant's own education level. No significant mediation effect was observed for any other mediators.

Conclusions: These data provide evidence that participant's mother's education was positively linked to adult TL in AA population. Participant's own educational level partially explained this association.

Keywords: African American; Childhood socioeconomic status; Mediator; Mother’s education; Path analysis; Telomere length.

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Conflict of interest statement

Authors declares no conflicts of interest

Figures

Fig. 1
Fig. 1
Estimated path analysis model showing the associations between mother’s education, potential mediators, and leukocyte TL (n=361): the GENE-FORECAST study
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