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. 2022 Jan;19(1):9-28.
doi: 10.1111/iwj.13601. Epub 2021 May 5.

The impact of resveratrol on skin wound healing, scarring, and aging

Andrzej Hecker  1   2 , Marlies Schellnegger  1   2 , Elisabeth Hofmann  1   2 , Hanna Luze  1   2 , Sebastian Philipp Nischwitz  1   2 , Lars-Peter Kamolz  1   2 , Petra Kotzbeck  1   2
Affiliations

The impact of resveratrol on skin wound healing, scarring, and aging

Andrzej Hecker et al. Int Wound J. 2022 Jan.

Abstract

Resveratrol is a well-known antioxidant that harbours many health beneficial properties. Multiple studies associated the antioxidant, anti-inflammatory, and cell protective effects of resveratrol. These diverse effects of resveratrol are also potentially involved in cutaneous wound healing, scarring, and (photo-)aging of the skin. Hence, this review highlighted the most relevant studies involving resveratrol in wound healing, scarring, and photo-aging of the skin. A systematic review was performed and the database PubMed was searched for suitable publications. Only original articles in English that investigated the effects of resveratrol in wound healing, scarring, and (photo-)aging of the skin were analysed. The literature search yielded a total of 826 studies, but only 41 studies met the inclusion criteria. The included studies showed promising results that resveratrol might be a feasible treatment approach to support wound healing, counteract excessive scarring, and even prevent photo-aging of the skin. Resveratrol represents an interesting and promising novel therapy regime but to confirm resveratrol-associated effects, more evidence based in vitro and in vivo studies are needed.

Keywords: chronic wound; resveratrol; scarring; skin aging; wound healing.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

FIGURE 1
FIGURE 1
Review process depicted in a flowchart
FIGURE 2
FIGURE 2
Resveratrol and its potential targets in wound healing, skin scarring, and photo‐aging
See this image and copyright information in PMC

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