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Meta-Analysis
. 2021 Apr-Jun;104(2):368504211013647.
doi: 10.1177/00368504211013647.

Association between interleukin-1 alpha rs1800587 polymorphism and rheumatoid arthritis: A meta-analysis

Huaguo Wang  1 , Yi Wang  2
Affiliations
Meta-Analysis

Association between interleukin-1 alpha rs1800587 polymorphism and rheumatoid arthritis: A meta-analysis

Huaguo Wang et al. Sci Prog. 2021 Apr-Jun.

Abstract

No consistent results have been reached on the relationship of interleukin-1 (IL-1) rs1800587 polymorphism with the susceptibility to rheumatoid arthritis (RA) so far. Therefore, the current meta-analysis was designed to thoroughly review relevant studies, in order to examine the relationship of IL-1A rs1800587 polymorphism with RA risk. Electronic databases were retrieved for literature regarding the relationship between IL-1A rs1800587 polymorphism and RA vulnerability according to the inclusion and exclusion criteria. Stata 12.0 software was adopted to examine the enrolled literature. Meanwhile, odds ratio (OR) and corresponding 95% confidence intervals (95% CI) were used to evaluate the association. A total of seven case-control researches (3267 patients and 2960 healthy controls) were eventually enrolled into the current meta-analysis. Our data indicated no correlation of IL-1A rs1800587 polymorphism with RA risk (TT vs CC: OR = 0.90, 95% CI = 0.73-1.11; TC vs CC: OR = 1.02, 95% CI = 0.78-1.34; Dominant model: OR = 1.04, 95% CI = 0.80-1.35; Recessive model: OR = 1.91, 95% CI = 0.74-1.12). Similarly, no association was found in subgroup analysis stratified by ethnicity. Our findings indicated no relationship between IL-1A rs1800587 polymorphism and RA vulnerability.

Keywords: IL-1 polymorphism; Rheumatoid arthritis; risk.

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Conflict of interest statement

The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Figures

Figure 1.
Figure 1.
The flowchart of the included studies in the meta-analysis.
Figure 2.
Figure 2.
Forest plot for meta-analysis of the association between the IL-1A rs1800587 and RA risk.
Figure 3.
Figure 3.
Sensitivity analysis of the IL-1A rs1800587 polymorphism.
Figure 4.
Figure 4.
Begg’s funnel plot analysis of the IL-1A rs1800587 polymorphism.
See this image and copyright information in PMC

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