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. 1988 May;32(5):758-60.
doi: 10.1128/AAC.32.5.758.

Animal model for evaluating the convulsive liability of beta-lactam antibiotics

P D Williams  1 , D B Bennett, C R Comereski
Affiliations

Animal model for evaluating the convulsive liability of beta-lactam antibiotics

P D Williams et al. Antimicrob Agents Chemother. 1988 May.

Abstract

The beta-lactam antibiotics imipenem-cilastatin, BMY-26225, and cefazolin significantly lowered the convulsive threshold of pentylenetetrazole in mice. In addition, imipenem-cilastatin and cefazolin were found to inhibit 3H-labeled gamma-aminobutyric acid binding to synaptic membranes from rat brains. Our results suggest that the pentylenetetrazole convulsive model may be useful in evaluating the proconvulsive liabilities of new carbapenems and other beta-lactam antibiotics and that the mechanism of imipenem-cilastatin and cefazolin toxicity may involve interaction with gamma-aminobutyric acid receptors.

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References

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