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Comment
. 2021 May 4;33(5):851-852.
doi: 10.1016/j.cmet.2021.04.010.

Immunotherapy breaches low-sugar dieting of tumor Treg cells

Clarissa Campbell  1 , Alexander Y Rudensky  2
Affiliations
Free article
Comment

Immunotherapy breaches low-sugar dieting of tumor Treg cells

Clarissa Campbell et al. Cell Metab. .
Free article

Abstract

Glycolysis supports effector T cell function but is detrimental to the immunosuppressive activity of regulatory T cells. In a recent issue of Nature, two papers address a role for glucose and lactate availability within the tumor microenvironment for the balance of pro- and anti-tumoral effects of T cells and the efficacy of neoadjuvant cancer immunotherapy.

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Conflict of interest statement

Declaration of interests A.Y.R. is an SAB member of and holds equity or stock options in Sonoma Biotherapeutic, Surface Oncology, RAPT Therapeutics, and Vedanta Biosciences. He is an SAB member of BioInvent and holds IP rights for therapeutic Treg cell depleting antibodies.

Comment on

  • CTLA-4 blockade drives loss of Treg stability in glycolysis-low tumours.
    Zappasodi R, Serganova I, Cohen IJ, Maeda M, Shindo M, Senbabaoglu Y, Watson MJ, Leftin A, Maniyar R, Verma S, Lubin M, Ko M, Mane MM, Zhong H, Liu C, Ghosh A, Abu-Akeel M, Ackerstaff E, Koutcher JA, Ho PC, Delgoffe GM, Blasberg R, Wolchok JD, Merghoub T. Zappasodi R, et al. Nature. 2021 Mar;591(7851):652-658. doi: 10.1038/s41586-021-03326-4. Epub 2021 Feb 15. Nature. 2021. PMID: 33588426 Free PMC article.

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