Mitochondria ensure immune surveillance by retro-communication with the nucleus

Manuel Rigon¹, Amelia R Townley², Michelangelo Campanella³

Affiliations

¹ Department of Comparative Biomedical Sciences, The Royal Veterinary College, University of London, Royal College Street, NW10TU London, UK; Department of Biology, University of Rome "Tor Vergata", 00133 Rome, Italy.
² Department of Comparative Biomedical Sciences, The Royal Veterinary College, University of London, Royal College Street, NW10TU London, UK.
³ Department of Comparative Biomedical Sciences, The Royal Veterinary College, University of London, Royal College Street, NW10TU London, UK; Department of Cell and Developmental Biology, Consortium for Mitochondrial Research (CfMR), University College London, Gower Street, WC1E6BT London, UK; Department of Biology, University of Rome "Tor Vergata", 00133 Rome, Italy. Electronic address: mcampanella@rvc.ac.uk.

PMID: 33951470
DOI: 10.1016/j.cmet.2021.04.013

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Mitochondria ensure immune surveillance by retro-communication with the nucleus

Manuel Rigon et al. Cell Metab. 2021.

Free article

. 2021 May 4;33(5):853-855.

doi: 10.1016/j.cmet.2021.04.013.

Authors

Manuel Rigon¹, Amelia R Townley², Michelangelo Campanella³

Affiliations

¹ Department of Comparative Biomedical Sciences, The Royal Veterinary College, University of London, Royal College Street, NW10TU London, UK; Department of Biology, University of Rome "Tor Vergata", 00133 Rome, Italy.
² Department of Comparative Biomedical Sciences, The Royal Veterinary College, University of London, Royal College Street, NW10TU London, UK.
³ Department of Comparative Biomedical Sciences, The Royal Veterinary College, University of London, Royal College Street, NW10TU London, UK; Department of Cell and Developmental Biology, Consortium for Mitochondrial Research (CfMR), University College London, Gower Street, WC1E6BT London, UK; Department of Biology, University of Rome "Tor Vergata", 00133 Rome, Italy. Electronic address: mcampanella@rvc.ac.uk.

PMID: 33951470
DOI: 10.1016/j.cmet.2021.04.013

Abstract

Mitochondria cover several functions within the cell, including an influence on the transcription of nuclear genes. Recent work by Tigano et al. (2021) in Nature has identified a pathway of mitochondrial retrograde communication in which the nucleus senses aberrations in the mtDNA to drive the innate immune response.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

Comment on

Nuclear sensing of breaks in mitochondrial DNA enhances immune surveillance.
Tigano M, Vargas DC, Tremblay-Belzile S, Fu Y, Sfeir A. Tigano M, et al. Nature. 2021 Mar;591(7850):477-481. doi: 10.1038/s41586-021-03269-w. Epub 2021 Feb 24. Nature. 2021. PMID: 33627873

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Mitochondria ensure immune surveillance by retro-communication with the nucleus

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Mitochondria ensure immune surveillance by retro-communication with the nucleus

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Abstract

Conflict of interest statement

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