Midlobular zone 2 hepatocytes: A gatekeeper of liver homeostasis

Naoto Kubota¹, Tetsuya Kubota², Takashi Kadowaki³

Affiliations

¹ Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
² Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan; Division of Diabetes and Metabolism, The Institute for Medical Science Asahi Life Foundation, Tokyo, Japan; Department of Clinical Nutrition, National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN), Tokyo, Japan; Laboratory for Intestinal Ecosystem, RIKEN Center for Integrative Medical Sciences (IMS), Yokohama, Japan.
³ Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan; Toranomon Hospital, Tokyo, Japan. Electronic address: kadowaki-3im@h.u-tokyo.ac.jp.

PMID: 33951471
DOI: 10.1016/j.cmet.2021.04.005

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Midlobular zone 2 hepatocytes: A gatekeeper of liver homeostasis

Naoto Kubota et al. Cell Metab. 2021.

Free article

. 2021 May 4;33(5):855-856.

doi: 10.1016/j.cmet.2021.04.005.

Authors

Naoto Kubota¹, Tetsuya Kubota², Takashi Kadowaki³

Affiliations

¹ Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
² Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan; Division of Diabetes and Metabolism, The Institute for Medical Science Asahi Life Foundation, Tokyo, Japan; Department of Clinical Nutrition, National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN), Tokyo, Japan; Laboratory for Intestinal Ecosystem, RIKEN Center for Integrative Medical Sciences (IMS), Yokohama, Japan.
³ Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan; Toranomon Hospital, Tokyo, Japan. Electronic address: kadowaki-3im@h.u-tokyo.ac.jp.

PMID: 33951471
DOI: 10.1016/j.cmet.2021.04.005

Abstract

The liver consists of different zones that vary in function depending on their lobular localization. It remained unclear which zone serves as a source of repopulating/regenerating hepatocytes; however, experiments by Wei et al. (2021) in 11 CreER knockin murine strains revealed a vital role for zone 2 hepatocytes in liver homeostasis.

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Conflict of interest statement

Declaration of interests The authors have no conflicts of interest to declare.

Comment on

Liver homeostasis is maintained by midlobular zone 2 hepatocytes.
Wei Y, Wang YG, Jia Y, Li L, Yoon J, Zhang S, Wang Z, Zhang Y, Zhu M, Sharma T, Lin YH, Hsieh MH, Albrecht JH, Le PT, Rosen CJ, Wang T, Zhu H. Wei Y, et al. Science. 2021 Feb 26;371(6532):eabb1625. doi: 10.1126/science.abb1625. Science. 2021. PMID: 33632817 Free PMC article.

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Midlobular zone 2 hepatocytes: A gatekeeper of liver homeostasis

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Midlobular zone 2 hepatocytes: A gatekeeper of liver homeostasis

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Conflict of interest statement

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