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. 2021 May 5;30(160):210025.
doi: 10.1183/16000617.0025-2021. Print 2021 Jun 30.

Interventions for the management of malignant pleural effusions: an updated network meta-analysis

Alex Dipper  1 , Hayley E Jones  2 , Rahul Bhatnagar  1 , Nancy J Preston  3 , Nick Maskell  4 , Amelia Clive  5
Affiliations

Interventions for the management of malignant pleural effusions: an updated network meta-analysis

Alex Dipper et al. Eur Respir Rev. .

Abstract

Talc slurry and poudrage are effective pleurodesis agents. IPCs have lower pleurodesis rates but comparable breathlessness control and reduced risk of repeat invasive procedures. It is essential that patients have access to a range of treatment strategies. https://bit.ly/38v30yw

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Conflict of interest statement

Provenance: Submitted article, peer reviewed. Conflict of interest: A. Dipper reports grants from National Institute for Health Research, during the conduct of the study. Conflict of interest: H.E. Jones reports grants from NICE Guidelines Technical Support Unit, University of Bristol, during the conduct of the study. Conflict of interest: R. Bhatnagar reports grants from National Institute for Health Research, during the conduct of the study; and was the trial coordinator for the TAPPS and IPC-Plus studies but did not perform the data extractions, or any assessments of risk of bias or GRADE, for these studies for the purposes of this article. Conflict of interest: N.J. Preston has nothing to disclose. Conflict of interest: N. Maskell reports grants from National Institute for Health Research, during the conduct of the study; and grants from Becton Dickenson, outside the submitted work. He was a member of the trial steering committee for TIME-1 and TIME-3 trials and co-author for one of the included studies in this article. He did not perform the data extractions, or any assessments of risk of bias or GRADE, for these studies for the purposes of this article. Conflict of interest: A. Clive reports grants from National Institute for Health Research, during the conduct of the study. She was involved in coordinating and recruiting to the TIME-3 trial and the TAPPS trial and assisted with the data analysis. She did not perform the data extraction, or any assessments of risk of bias or GRADE, for these studies for the purpose of this article.

References

    1. Bibby AC, Dorn P, Psallidas I, et al. . ERS/EACTS statement on the management of malignant pleural effusions. Eur J Cardiothorac Surg 2019; 55: 116–132. doi:10.1093/ejcts/ezy258 - DOI - PubMed
    1. Clive AO, Jones HE, Bhatnagar R, et al. . Interventions for the management of malignant pleural effusions: a network meta-analysis. Cochrane Database Syst Rev 2016; 5: CD010529. doi: 10.1002/14651858.CD010529.pub2 - DOI - PMC - PubMed
    1. Dipper A, Jones HE, Bhatnagar R, et al. . Interventions for the management of malignant pleural effusions: a network meta-analysis. Cochrane Database Syst Rev 2020; 4: CD010529. doi: 10.1002/14651858.CD010529.pub3 - DOI - PMC - PubMed

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