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. 1988 Jul 15;154(1):199-204.
doi: 10.1016/0006-291x(88)90670-5.

A possible recognition mode of mRNA cap terminal structure by peptide: cooperative stacking and hydrogen-bond pairing interactions between m7GpppA and Trp-Leu-Glu

H Ueda  1 , M Doi, M Inoue, T Ishida, T Tanaka, S Uesugi
Affiliations

A possible recognition mode of mRNA cap terminal structure by peptide: cooperative stacking and hydrogen-bond pairing interactions between m7GpppA and Trp-Leu-Glu

H Ueda et al. Biochem Biophys Res Commun. .

Abstract

1H-NMR and fluorescence spectroscopic studies on the interaction between the Trp-Leu-Glu and m7GpppA have shown a specific binding mode, in which the pi-pi stacking interaction of the Trp indole ring and the hydrogen-bond pairing of Glu carboxyl side group with 7-methylguanine base are simultaneously formed.

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