doi: 10.1016/0006-291x(88)90676-6.
Stimulation of heart sarcolemmal Na+-Ca2+ exchange by concanavalin A
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- PMID: 3395327
- DOI: 10.1016/0006-291x(88)90676-6
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Stimulation of heart sarcolemmal Na+-Ca2+ exchange by concanavalin A
Biochem Biophys Res Commun.
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Abstract
The effects of Concanavalin A (Con A) on membrane Ca2+ translocation activities were examined by employing rat heart sarcolemmal preparations. Con A stimulated Na+-dependent Ca2+ uptake and ATP-dependent Ca2+ uptake activities in the sarcolemmal vesicles; maximal stimulation was seen at a concentration of 10 microgram/ml. These effects of Con A were blocked by alpha-metylmannoside. Sarcolemmal Na+-induced Ca2+ release was not affected by Con A. It is suggested that Con A-like substances may play a regulatory role in Ca2+-translocation processes of heart sarcolemma.
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