Keep your Sox on, chondrocytes!
- PMID: 33953371
- DOI: 10.1038/s41584-021-00628-9
Keep your Sox on, chondrocytes!
Comment on
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SOX9 keeps growth plates and articular cartilage healthy by inhibiting chondrocyte dedifferentiation/osteoblastic redifferentiation.Proc Natl Acad Sci U S A. 2021 Feb 23;118(8):e2019152118. doi: 10.1073/pnas.2019152118. Proc Natl Acad Sci U S A. 2021. PMID: 33597301 Free PMC article.
References
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- Lefebvre, V. & Dvir-Ginzberg, M. SOX9 and the many facets of its regulation in the chondrocyte lineage. Connect. Tissue Res. 58, 2–14 (2017). - DOI
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- Henry, S. P. et al. The postnatal role of Sox9 in cartilage. J. Bone Miner. Res. 27, 2511–2525 (2012). - DOI
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- Haseeb, A. et al. SOX9 keeps growth plates and articular cartilage healthy by inhibiting chondrocyte dedifferentiation/osteoblastic redifferentiation. Proc. Natl Acad. Sci. USA 118, e2019152118 (2021). - DOI
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- Bali, S. K. et al. Glycogen synthase kinase 3 alpha/beta deletion induces precocious growth plate remodeling in mice. J. Mol. Med. (Berl.) https://doi.org/10.1007/s00109-021-02049-3 (2021). - DOI
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- Staines, K. A. et al. Endochondral growth defect and deployment of transient chondrocyte behaviors underlie osteoarthritis onset in a natural murine model. Arthritis Rheumatol. 68, 880–891 (2016). - DOI
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