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Review
. 2021 Dec;31(8):1583-1596.
doi: 10.1007/s00590-021-02990-6. Epub 2021 May 6.

The role of radiotherapy in adult soft tissues sarcoma of the extremities

Silvia Cammelli  1   2 , Annalisa Cortesi  3 , Milly Buwenge  4   5 , Alice Zamagni  4   5 , Martina Ferioli  4   5 , Giulia Ghigi  3 , Antonino Romeo  3 , Alessio G Morganti  4   5
Affiliations
Review

The role of radiotherapy in adult soft tissues sarcoma of the extremities

Silvia Cammelli et al. Eur J Orthop Surg Traumatol. 2021 Dec.

Abstract

Local management of adult soft tissue sarcoma of the extremities has evolved over the past decades. Until the 1970s, radical surgery (amputations) was the standard therapeutic procedure resulting in significant physical and psychological morbidity for the patients. In the present era, limb sparing surgery combined with radiotherapy represents the current standard of care for high grade and > 5 cm STSs. This approach guarantees high local control rate and function preservation. The aim of this paper is to summarize the current evidence for RT in STSs of the extremities. Outcomes, technical details (techniques, timing, dose, volumes of treatment) and the emerging role of RT in the management of oligometastatic disease will be analysed. Finally, results of the recent clinical trials testing new scenarios in RT of STSs will be described.

Keywords: Extremities; Limbs; Radiotherapy; Review; Soft tissue sarcoma.

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Conflict of interest statement

The authors have no relevant financial or non-financial interests to disclose regarding this article.

Figures

Fig. 1
Fig. 1
example of isodose distribution for a patient with soft tissue sarcoma of the thigh treated with volumetric modulated arc therapy (VMAT)
Fig. 2
Fig. 2
Example of target delineation for a patient with soft tissue sarcoma of the thigh. Yellow line represents gross tumour volume (GTV). Red line represents planning target volume (PTV)
See this image and copyright information in PMC

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