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Review
. 2021 Sep;51(9):e13578.
doi: 10.1111/eci.13578. Epub 2021 May 25.

Polycystic οvary syndrome revisited: An interactions network approach

Styliani A Geronikolou  1   2 , Athanasia Pavlopoulou  3   4 , Dennis V Cokkinos  1 , Flora Bacopoulou  2 , George P Chrousos  1   2
Affiliations
Review

Polycystic οvary syndrome revisited: An interactions network approach

Styliani A Geronikolou et al. Eur J Clin Invest. 2021 Sep.

Abstract

Background: The polycystic ovary syndrome (PCOS) has genetic, epigenetic, metabolic and reproductive aspects, while its complex pathophysiology has not been conclusively deciphered.

Aim: The goal of this research was to screen the gene/gene products associated with PCOS and to predict any possible interactions with the highest possible fidelity.

Materials and methods: STRING v10.5 database and a confidence level of 0.7 were used.

Results: A highly interconnected network of 48 nodes was created, where insulin (INS) appears to be the major hub. INS upstream and downstream defects were analysed and revealed that only the kisspeptin- and glucagon-coding genes were upstream of INS.

Conclusion: A metabolic dominance was inferred and discussed herein with its implications in puberty, obesity, infertility and cardiovascular function. This study, thus, may contribute to the resolution of a scientific conflict between the USA and EU definitions of the syndrome and/or provide a new P4 medicine approach.

Keywords: P4 medicine; insulin; interactome; polycystic ovary syndrome; systems medicine; thermoregulation.

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References

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