Neutrophil Extracellular Traps as Prognostic Markers in COVID-19: A Welcome Piece to the Puzzle
- PMID: 33955780
- PMCID: PMC7837687
- DOI: 10.1161/ATVBAHA.120.315633
Neutrophil Extracellular Traps as Prognostic Markers in COVID-19: A Welcome Piece to the Puzzle
Keywords: Editorials; chromatin; coronavirus; cytokines; extracellular traps; neutrophils.
Conflict of interest statement
Dr Lang has relationships with drug companies, including AOPOrphan Pharmaceuticals AG, Actelion-Janssen, MSD, United Therapeutics, Medtronic, and Ferrer. In addition to being investigator in trials involving these companies, relationships include consultancy service, research grants, and membership of scientific advisory boards. The other author reports no conflicts.
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Circulating Markers of Neutrophil Extracellular Traps Are of Prognostic Value in Patients With COVID-19.Arterioscler Thromb Vasc Biol. 2021 Feb;41(2):988-994. doi: 10.1161/ATVBAHA.120.315267. Epub 2020 Dec 3. Arterioscler Thromb Vasc Biol. 2021. PMID: 33267662 Free PMC article.
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References
-
- Ng H, Havervall S, Rosell A, Aguilera K, Parv K, von Meijenfeldt FA, Lisman T, Mackman N, Thålin C, Phillipson M. Circulating markers of neutrophil extracellular traps are of prognostic value in patients with COVID-19. Arterioscler Thromb Vasc Biol. 2021;41:988–994. doi: 10.1161/ATVBAHA.120.315267 - PMC - PubMed
-
- Brinkmann V, Reichard U, Goosmann C, Fauler B, Uhlemann Y, Weiss DS, Weinrauch Y, Zychlinsky A. Neutrophil extracellular traps kill bacteria. Science. 2004;303:1532–1535. doi: 10.1126/science.1092385 - PubMed
-
- Jorch SK, Kubes P. An emerging role for neutrophil extracellular traps in noninfectious disease. Nat Med. 2017;23:279–287. doi: 10.1038/nm.4294 - PubMed
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