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Editorial
. 2021 May 6;137(18):2422-2423.
doi: 10.1182/blood.2020009748.

"Root"ing for successful T-ALL treatment

Sathish K R Padi  1 , Andrew S Kraft  2
Affiliations
Editorial

"Root"ing for successful T-ALL treatment

Sathish K R Padi et al. Blood. .

Abstract

In this issue of Blood, Anand et al provide compelling evidence that resistance to Notch inhibitor therapy in early T-cell precursor acute lymphoblastic leukemia (ETP-ALL) occurs as a result of an activated phosphatidylinositol 3-kinase (PI3K) pathway. To further decipher the resistance mechanism, the investigators performed single-cell RNA sequencing analysis on the bone marrow of 5 patients treated with the γ-secretase inhibitor (GSI) BMS-906024 and found 13 different cell clusters, of which 6 were specific to leukemia patients.

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Conflict of interest statement

Conflict-of-interest disclosure: The authors declare no competing financial interests.

Conflict-of-interest disclosure: The authors declare no competing financial interests.

Figures

None
As shown in Amand et al, the demonstration of 2 different root cells generated from single-cell sequencing. Root cells are shown interacting with T cells through the expression of HAVCR2 (Galectin-9) and LGALS9 (TIM-3). The figure has been adapted from the visual abstract in the article by Anand et al that begins on page 2463.
See this image and copyright information in PMC

Comment on

References

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    1. Coustan-Smith E, Mullighan CG, Onciu M, et al. . Early T-cell precursor leukaemia: a subtype of very high-risk acute lymphoblastic leukaemia. Lancet Oncol. 2009;10(2):147-156. - PMC - PubMed
    1. Zhang J, Ding L, Holmfeldt L, et al. . The genetic basis of early T-cell precursor acute lymphoblastic leukaemia. Nature. 2012;481(7380):157-163. - PMC - PubMed
    1. Liu Y, Easton J, Shao Y, et al. . The genomic landscape of pediatric and young adult T-lineage acute lymphoblastic leukemia. Nat Genet. 2017;49(8):1211-1218. - PMC - PubMed
    1. Knoechel B, Bhatt A, Pan L, et al. . Complete hematologic response of early T-cell progenitor acute lymphoblastic leukemia to the γ-secretase inhibitor BMS-906024: genetic and epigenetic findings in an outlier case. Cold Spring Harb Mol Case Stud. 2015;1(1):a000539. - PMC - PubMed

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