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Comment
. 2021 Jun 7;153(6):e202112929.
doi: 10.1085/jgp.202112929. Epub 2021 May 6.

Unconventional voltage sensing in an inwardly rectifying potassium channel

Harley T Kurata  1
Affiliations
Comment

Unconventional voltage sensing in an inwardly rectifying potassium channel

Harley T Kurata. J Gen Physiol. .

Abstract

Inwardly rectifying potassium channels are generally thought to achieve their physiological voltage dependence via an “extrinsic” mechanism involving voltage-dependent block by polyamines. A surprising finding of polyamine-independent gating of Kir4.1/Kir5.1 heteromeric channels suggests a mechanism of voltage dependence arising from interactions with permeating ions.

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References

    1. Casamassima, M., D’Adamo M.C., Pessia M., and Tucker S.J.. 2003. Identification of a heteromeric interaction that influences the rectification, gating, and pH sensitivity of Kir4.1/Kir5.1 potassium channels. J. Biol. Chem. 278:43533–43540. 10.1074/jbc.M306596200 - DOI - PubMed
    1. Elvington, S.M., Liu C.W., and Maduke M.C.. 2009. Substrate-driven conformational changes in ClC-ec1 observed by fluorine NMR. EMBO J. 28:3090–3102. 10.1038/emboj.2009.259 - DOI - PMC - PubMed
    1. Guo, D., and Lu Z.. 2002. IRK1 inward rectifier K+ channels exhibit no intrinsic rectification. J. Gen. Physiol. 120:539–551. 10.1085/jgp.20028623 - DOI - PMC - PubMed
    1. Guo, D., and Lu Z.. 2003. Interaction mechanisms between polyamines and IRK1 inward rectifier K+ channels. J. Gen. Physiol. 122:485–500. 10.1085/jgp.200308890 - DOI - PMC - PubMed
    1. Hibino, H., Inanobe A., Furutani K., Murakami S., Findlay I., and Kurachi Y.. 2010. Inwardly rectifying potassium channels: their structure, function, and physiological roles. Physiol. Rev. 90:291–366. 10.1152/physrev.00021.2009 - DOI - PubMed

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