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Comment
. 2021 May 5;109(9):1423-1425.
doi: 10.1016/j.neuron.2021.04.009.

The astrocyte LAMP lights a T cell TRAIL of death

Lisa Johann  1 , Ari Waisman  2
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The astrocyte LAMP lights a T cell TRAIL of death

Lisa Johann et al. Neuron. .
Free article

Abstract

In a recent issue of Nature, Sanmarco et al. reveal a novel mechanism by which astrocytes maintain an anti-inflammatory state in the central nervous system (CNS). IFNγ released by gut-licensed meningeal NK cells was found to induce TRAIL expression on astrocytes, causing effector T cell apoptosis.

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  • Gut-licensed IFNγ+ NK cells drive LAMP1+TRAIL+ anti-inflammatory astrocytes.
    Sanmarco LM, Wheeler MA, Gutiérrez-Vázquez C, Polonio CM, Linnerbauer M, Pinho-Ribeiro FA, Li Z, Giovannoni F, Batterman KV, Scalisi G, Zandee SEJ, Heck ES, Alsuwailm M, Rosene DL, Becher B, Chiu IM, Prat A, Quintana FJ. Sanmarco LM, et al. Nature. 2021 Feb;590(7846):473-479. doi: 10.1038/s41586-020-03116-4. Epub 2021 Jan 6. Nature. 2021. PMID: 33408417 Free PMC article.

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