Human cells and networks of pain: Transforming pain target identification and therapeutic development

William Renthal¹, Alexander Chamessian², Michele Curatolo³, Steve Davidson⁴, Michael Burton⁵, Sulayman Dib-Hajj⁶, Patrick M Dougherty⁷, Allison D Ebert⁸, Robert W Gereau 4th², Andre Ghetti⁹, Michael S Gold¹⁰, Gwendolyn Hoben¹¹, Daniela Maria Menichella¹², Philippe Mercier¹³, Wilson Z Ray¹⁴, Daniela Salvemini¹⁵, Rebecca P Seal¹⁰, Stephen Waxman⁶, Clifford J Woolf¹⁶, Cheryl L Stucky¹⁷, Theodore J Price¹⁸

Affiliations

¹ Department of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA. Electronic address: wrenthal@bwh.harvard.edu.
² Department of Anesthesiology, Washington University Pain Center, Washington University School of Medicine, St Louis, MO 63110, USA.
³ Department of Anesthesiology and Pain Medicine, CLEAR Center for Musculoskeletal Disorder, Harborview Injury Prevention and Research Center, University of Washington, Seattle, WA 98195, USA.
⁴ Department of Anesthesiology, University of Cincinnati, College of Medicine, Cincinnati, OH 45267, USA.
⁵ Department of Neuroscience and Center for Advanced Pain Studies, University of Texas at Dallas, Richardson, TX 75080, USA.
⁶ Department of Neurology and Center for Neuroscience and Regeneration Research, Yale University School of Medicine, New Haven, CT 06510, USA; Center for Rehabilitation Research, VA Connecticut Healthcare System, West Haven, CT 06516, USA.
⁷ Department of Pain Medicine, Division of Anesthesiology and Critical Care, The University of Texas MD Anderson Cancer Center, Houston, TX 78712, USA.
⁸ Department of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
⁹ AnaBios Corporation, San Diego, CA 92109, USA.
¹⁰ Department of Neurobiology, Pittsburgh Center for Pain Research, University of Pittsburgh, Pittsburgh, PA 15260, USA.
¹¹ Department of Plastic Surgery, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
¹² Department of Neurology and Pharmacology, Northwestern University Feinberg Medical School, Chicago, IL 60611, USA.
¹³ Department of Neurosurgery and Henry and Amelia Nasrallah Center for Neuroscience, Saint Louis University, St. Louis, MO 63117, USA.
¹⁴ Department of Neurosurgery, Washington University School of Medicine, St. Louis, MO 63110, USA.
¹⁵ Department of Pharmacology and Physiology and Henry and Amelia Nasrallah Center for Neuroscience, Saint Louis University, St. Louis, MO 63103, USA.
¹⁶ F.M. Kirby Neurobiology Center, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.
¹⁷ Department of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, WI 53226, USA. Electronic address: cstucky@mcw.edu.
¹⁸ Department of Neuroscience and Center for Advanced Pain Studies, University of Texas at Dallas, Richardson, TX 75080, USA. Electronic address: theodore.price@utdallas.edu.

PMID: 33957072
PMCID: PMC9208579
DOI: 10.1016/j.neuron.2021.04.005

Human cells and networks of pain: Transforming pain target identification and therapeutic development

William Renthal et al. Neuron. 2021.

. 2021 May 5;109(9):1426-1429.

doi: 10.1016/j.neuron.2021.04.005.

Authors

Affiliations

¹ Department of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA. Electronic address: wrenthal@bwh.harvard.edu.
² Department of Anesthesiology, Washington University Pain Center, Washington University School of Medicine, St Louis, MO 63110, USA.
³ Department of Anesthesiology and Pain Medicine, CLEAR Center for Musculoskeletal Disorder, Harborview Injury Prevention and Research Center, University of Washington, Seattle, WA 98195, USA.
⁴ Department of Anesthesiology, University of Cincinnati, College of Medicine, Cincinnati, OH 45267, USA.
⁵ Department of Neuroscience and Center for Advanced Pain Studies, University of Texas at Dallas, Richardson, TX 75080, USA.
⁶ Department of Neurology and Center for Neuroscience and Regeneration Research, Yale University School of Medicine, New Haven, CT 06510, USA; Center for Rehabilitation Research, VA Connecticut Healthcare System, West Haven, CT 06516, USA.
⁷ Department of Pain Medicine, Division of Anesthesiology and Critical Care, The University of Texas MD Anderson Cancer Center, Houston, TX 78712, USA.
⁸ Department of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
⁹ AnaBios Corporation, San Diego, CA 92109, USA.
¹⁰ Department of Neurobiology, Pittsburgh Center for Pain Research, University of Pittsburgh, Pittsburgh, PA 15260, USA.
¹¹ Department of Plastic Surgery, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
¹² Department of Neurology and Pharmacology, Northwestern University Feinberg Medical School, Chicago, IL 60611, USA.
¹³ Department of Neurosurgery and Henry and Amelia Nasrallah Center for Neuroscience, Saint Louis University, St. Louis, MO 63117, USA.
¹⁴ Department of Neurosurgery, Washington University School of Medicine, St. Louis, MO 63110, USA.
¹⁵ Department of Pharmacology and Physiology and Henry and Amelia Nasrallah Center for Neuroscience, Saint Louis University, St. Louis, MO 63103, USA.
¹⁶ F.M. Kirby Neurobiology Center, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.
¹⁷ Department of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, WI 53226, USA. Electronic address: cstucky@mcw.edu.
¹⁸ Department of Neuroscience and Center for Advanced Pain Studies, University of Texas at Dallas, Richardson, TX 75080, USA. Electronic address: theodore.price@utdallas.edu.

PMID: 33957072
PMCID: PMC9208579
DOI: 10.1016/j.neuron.2021.04.005

Abstract

Chronic pain is a disabling disease with limited treatment options. While animal models have revealed important aspects of pain neurobiology, therapeutic translation of this knowledge requires our understanding of these cells and networks of pain in humans. We propose a multi-institutional collaboration to rigorously and ethically address this challenge.

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Conflict of interest statement

Declaration of interests A.G. is an employee and shareholder of AnaBios. C.J.W. is a founder of Nocion Therapeutics and QurAlis and SAB member at Cygnal Therapeutics and EnClear Therapeutics. M.S.G. has grant support from Grunenthal. S.D. is a founder of Metabodose. T.J.P. is founder of Doloromics and 4E Therapeutics, a shareholder of Acadia Pharma, and a consultant for Biogen and Grunenthal and holds research grants from Merck, Grunenthal, and Hoba Therapeutics. W.R. is a consultant for Kallyope. W.Z.R. receives royalties from Johnson & Johnson, Acera, and Corelink and is a consultant for Globus Medical, Nuvasive, and Syntax.

Figures

**Figure 1.**
The centers of the Human Cells and Networks of Pain Consortium

See this image and copyright information in PMC

References

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Human cells and networks of pain: Transforming pain target identification and therapeutic development

Affiliations

Human cells and networks of pain: Transforming pain target identification and therapeutic development

Authors

Affiliations

Abstract

Conflict of interest statement

Figures

References

Publication types

MeSH terms

Grants and funding

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical