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. 2021 Dec 13;51(6):2897-2902.
doi: 10.3906/sag-2012-247.

Effect of hyperparathyroidism on coagulation: a global assessment by modified rotation thromboelastogram (ROTEM)

Göknur Yorulmaz  1 , Ahmet Toygar Kalkan  1 , Aysen Akalin  1 , Elif Sevil Alagüney  1 , Eren Gündüz  2 , Bartu Badak  3 , Betül Aydin Buyruk  1 , Nur Kebapçı  1 , Belgin Efe  1 , Muzaffer Bilgin  4 , Olga Meltem Akay  5
Affiliations

Effect of hyperparathyroidism on coagulation: a global assessment by modified rotation thromboelastogram (ROTEM)

Göknur Yorulmaz et al. Turk J Med Sci. .

Abstract

Background/aim: Hyperparathyroidism is an endocrine disorder characterized by hypercalcemia. Because of calcium’s effects on parathyroid glands, bone, intestines, and kidneys, it has an important place in homeostasis. The results of studies regarding hyperparathyroidism hemostasis are conflicting. Thromboelastography helps to evaluate all steps of hemostatic system. Our aim in this study was to investigate the possible role of hemostatic mechanisms in the development of thrombosis in hyperparathyroid patients with the modified rotation thromboelastogram (ROTEM).

Materials and methods: Twenty-two patients with primary hyperparathyroidism (PHPT) and 20 healthy controls were involved. This study was conducted in Eskisehir Osmangazi University Faculty of Medicine, Endocrinology and Hematology clinics for 2 years. The complete blood count, fibrinogen, D-dimer levels, prothrombin time, activated prothrombin time, and ROTEM parameters [clot formation time (CFT), clotting time (CT), and maximum clot formation (MCF)] were determined by two activated tests, INTEM and EXTEM analyses. A thromboelastographic evaluation was performed in the preoperative and postoperative (3 months after surgery) periods.

Results: In INTEM assay, the CT (p = 0.012) and CFT (p = 0.07) values were increased in preoperative PHPT patients compared with the control group. Although there was a decrease in the postoperative CT and CFT values, no statistical difference was found.

Conclusion: The prolongation of the CT and CFT values were consistent with a hypocoagulable state in patients with PHPT. Hyperparathyroidism causes a hypocoagulable state that can be successfully assessed by ROTEM. Hemostatic changes, do not seem to have an effect on increased cardiovascular mortality.

Keywords: ROTEM; coagulation; hyperparathyroidism; thromboelastogram.

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Conflict of interest statement

None declared.

References

    1. Hedback G, Tisell LE, Bengtsson BA, Hedman I, Oden A. Premature death in patients operated on for PHPT. World Journal of Surgery. 1990;14:829–835. doi: 10.1007/BF01670531. - DOI - PubMed
    1. Walker MD, Silverberg SJ. Primary hyperparathyroidism. Nature Reviews Endocrinology. 2018;14(2):115–125. doi: 10.1038/nrendo.2017.104. - DOI - PMC - PubMed
    1. Erem C, Kocak M, Hacihasanoglu A, Yılmaz M, Saglam F, et al. Blood coagulation; fibrinolysis and lipid profile in patients with primary hyperparathyroidism: increased plasma factor VII and X activities and D-dimer levels. Experimental and Clinical Endocrinology & Diabetes. 2008;116:619–624. doi: 10.1055/s-2008-1065365. - DOI - PubMed
    1. Erem C, Kocak M, Nuhoglu I, Yılmaz M, Ucuncu O. Increased plasma activator inhibitor-1, decreased tissue factor pathway inhibitor, and unchanged thrombin-activatable fibrinolysis inhibitor levels in patients with primary hyperparathyroidism. European Journal of Endocrinology. 2009;160:863–868. doi: 10.1530/EJE-09-0069. - DOI - PubMed
    1. Franchello A, Camandona M, Gasparri G. Acute hyperparathyroidism and vascular thrombosis: an unrecognized association. Journal of Endocrinological Investigation. 2010;33(9):683. doi: 10.1007/BF03346669. - DOI - PubMed

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