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Comment
. 2021 Jun;31(6):607-608.
doi: 10.1038/s41422-021-00502-z.

Panning for brain antigens in dural sinuses

Ania Bogoslowski  1 , Paul Kubes  2
Affiliations
Comment

Panning for brain antigens in dural sinuses

Ania Bogoslowski et al. Cell Res. 2021 Jun.
No abstract available

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Figures

Fig. 1
Fig. 1. Similarities between antigen surveillance in the lymph node and the dural sinuses.
In the lymph node, antigen enters through the afferent lymphatic vessels and is picked up by macrophages in the subcapsular sinus and dendritic cells in the parenchyma for antigen presentation. T cells enter through high endothelial venules, a process carefully controlled by L-selectin interactions. In the brain, antigen drains from the brain through the subarachnoid space and into the Dura. Here, antigen presenting cells pick up brain antigen and present it to T cells which infiltrate through the superior sagittal sinus in a VLA4/LFA/PSGL-1 dependant manner.
See this image and copyright information in PMC

Comment on

  • Functional characterization of the dural sinuses as a neuroimmune interface.
    Rustenhoven J, Drieu A, Mamuladze T, de Lima KA, Dykstra T, Wall M, Papadopoulos Z, Kanamori M, Salvador AF, Baker W, Lemieux M, Da Mesquita S, Cugurra A, Fitzpatrick J, Sviben S, Kossina R, Bayguinov P, Townsend RR, Zhang Q, Erdmann-Gilmore P, Smirnov I, Lopes MB, Herz J, Kipnis J. Rustenhoven J, et al. Cell. 2021 Feb 18;184(4):1000-1016.e27. doi: 10.1016/j.cell.2020.12.040. Epub 2021 Jan 27. Cell. 2021. PMID: 33508229 Free PMC article.

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