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Review
. 2021 Jun;12(12):1917-1922.
doi: 10.1111/1759-7714.13963. Epub 2021 May 7.

Primary ciliated muconodular papillary tumor: A rare pulmonary disease and literature review of 65 cases

Yanye Wang  1   2 , Dan Wang  3 , Jun Wang  4 , Shikang Zhao  1   2 , Dian Ren  1   2 , Gang Chen  1   2 , Qiuhui Wang  5 , Dongbo Xu  3 , Song Xu  1   2
Affiliations
Review

Primary ciliated muconodular papillary tumor: A rare pulmonary disease and literature review of 65 cases

Yanye Wang et al. Thorac Cancer. 2021 Jun.

Abstract

A ciliated muconodular papillary tumor (CMPT) or bronchiolar adenoma (BA) is a rather rare and unique type of lung tumor characterized by tripartite cellular components with a papillary-predominant structure including ciliated columnar cells, mucinous cells, and basal cells. Here, we present the case of a 64-year-old woman who was diagnosed with CMPT in our center. In addition to reporting the clinicopathological characteristics of this case, we also conducted whole exome sequencing (WES) to explore the underlying mechanism. According to current evidence, CMPTs tends to be benign or of low grade malignancy. However, this requires further validation.

Keywords: PD-L1; bronchiolar adenoma (BA); ciliated muconodular papillary tumor (CMPT); sequencing; surgery.

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Conflict of interest statement

All authors report no conflicts of interest.

Figures

FIGURE 1
FIGURE 1
(a, b) Contrast‐enhanced computed tomography (CT) indicated an irregular solid nodule with a maximum diameter of 1.2 cm in the dorsal segment of the right lower pulmonary lobe. (c, d, e) 18F‐FDG CT‐PET showed focal hyperaccumulation within the pulmonary artery and hilum and mediastinal lymph nodes (LNs)
FIGURE 2
FIGURE 2
(a) Histopathological examination with hematoxylin and eosin (H&E) staining confirmed the lesions were surrounded by copious amounts of mucus and consist of ciliated columnar cells, mucous cells, and basal cells (×40, ×100). PD‐L1 expression (22C3 Darko antibody) in the solid nodule tissue (×200, ×400). (b) The patient's whole genome CNV model ideograph (red = gain, blue = loss). (c) Patient's protein–protein interaction (PPI) network complex analysis (154 upregulated in orange [upregulation] and 421 downregulated genes in blue [downregulation])
See this image and copyright information in PMC

References

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