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Editorial
. 2021 May:16:455-459.
doi: 10.2217/fmb-2020-0300. Epub 2021 May 7.

Glimpses into evolutionary trajectories of SARS-CoV-2: emerging variants and potential immune evasion routes

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Editorial

Glimpses into evolutionary trajectories of SARS-CoV-2: emerging variants and potential immune evasion routes

Cleo Anastassopoulou et al. Future Microbiol. 2021 May.

Abstract

Tweetable abstract An opinion on the coronaviruses' evolution paradoxes, the continuing adaptation of the SARS-CoV-2 in humans following the zoonotic transmission, and clues into escape routes from host immune responses.

Keywords: APOBEC; COVID-19; SARS-CoV-2 variants of concern; adaptation; coronavirus; genetic diversity; genome evolution; immune escape; spike; vaccines.

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References

    1. Bull JJ, Sanjuan R, Wilke CO. Theory of lethal mutagenesis for viruses. J. Virol. 81(6), 2930–2939 (2007). - PMC - PubMed
    1. Eigen M. Error catastrophe and antiviral strategy. Proc. Natl Acad. Sci. USA 99(21), 13374–13376 (2002). - PMC - PubMed
    1. Nga PT, Parquet MC, Lauber C et al. Discovery of the first insect nido-virus, a missing evolutionary link in the emergence of the largest RNA virus genomes. PLoS Pathog. 7(9), e1002215 (2011). - PMC - PubMed
    1. Smith EC, Denison MR. Implications of altered replication fidelity on the evolution and pathogenesis of coronaviruses. Curr. Opin. Virol. 2(5), 519–524 (2012). - PMC - PubMed
    1. Saberi A, Gulyaeva AA, Brubacher JL, Newmark PA, Gorbalenya AE. A planarian nidovirus expands the limits of RNA genome size. PLoS Pathog. 14(11), e1007314 (2018). - PMC - PubMed

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