doi: 10.1016/0309-1651(88)90123-3.
Nuclear matrix-intermediate filament system and its alteration in adenovirus infected HeLa cell
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- PMID: 3396082
- DOI: 10.1016/0309-1651(88)90123-3
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Nuclear matrix-intermediate filament system and its alteration in adenovirus infected HeLa cell
Cell Biol Int Rep.
1988 Feb.
Abstract
The nuclear matrix-intermediate filament (NM-IF) of normal and adenovirus infected HeLa cells were investigated by means of both electron microscopy and two-dimensional gel electrophoresis. After infection there were some changes in NM-IF, and the viral factory was suspended in nuclear matrix. Two new polypeptides appeared in 2-D gel of NM-IF after infection. They are probably not viral proteins but cellular polypeptides. During viral replication, all of vimentin were degraded and phosphorylated keratin 18 increased. These facts suggest that NM-IF plays a certain role in adenovirus replication.
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