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Meta-Analysis
. 2021 May 7;5(5):CD001150.
doi: 10.1002/14651858.CD001150.pub4.

Topical emollient for preventing infection in preterm infants

Jemma Cleminson  1 , William McGuire  1
Affiliations
Meta-Analysis

Topical emollient for preventing infection in preterm infants

Jemma Cleminson et al. Cochrane Database Syst Rev. .

Abstract

Background: Breakdown of the developmentally immature epidermal barrier may permit entry for micro-organisms leading to invasive infection in preterm infants. Topical emollients may improve skin integrity and barrier function and thereby prevent invasive infection, a major cause of mortality and morbidity in preterm infants.

Objectives: To assess the effect of topical application of emollients (ointments, creams, or oils) on the risk of invasive infection and mortality in preterm infants.

Search methods: We searched CENTRAL via Cochrane Register of Studies (CRS) Web and MEDLINE via Ovid (updated 08 January 2021) and the reference lists of retrieved articles.

Selection criteria: Randomised or quasi-randomised controlled trials that assessed the effect of prophylactic application of topical emollient on the risk of invasive infection, mortality, other morbidity, and growth and development in preterm infants.

Data collection and analysis: We used the standard methods of Cochrane Neonatal. Two review authors separately evaluated trial quality, extracted data, and synthesised effect estimates using risk ratio (RR), risk difference (RD), and mean difference. We used the GRADE approach to assess the certainty of evidence for effects on mortality and invasive infection.

Main results: We included 22 trials with a total of 5578 infant participants. The main potential sources of bias were lack of clarity on the methods used to generate random sequences and conceal allocation in half of the trials, and lack of masking of parents, caregivers, clinicians, and investigators in all of the trials. Eight trials (2086 infants) examined the effect of topical ointments or creams. Most participants were very preterm infants cared for in healthcare facilities in high-income countries. Meta-analyses suggested that topical ointments or creams may have little or no effect on invasive infection (RR 1.13, 95% confidence interval (CI) 0.97 to 1.31; low certainty evidence) or mortality (RR 0.94, 95% CI 0.82 to 1.08; low certainty evidence). Fifteen trials (3492 infants) assessed the effect of topical plant or vegetable oils. Most of these trials were undertaken in low- or middle-income countries and were based in healthcare facilities. One large (2249 infants) community-based trial occurred in a rural field practice in India. Meta-analyses suggested that topical oils may reduce invasive infection (RR 0.71, 95% CI 0.52 to 0.96; I² = 52%; low certainty evidence) but have little or no effect on mortality (RR 0.94, 95% CI 0.82 to 1.08, I² = 3%; low certainty evidence). One trial (316 infants) that compared petroleum-based ointment versus sunflower seed oil in very preterm infants in Bangladesh showed little or no effect on invasive infection (RR 0.91, 95% CI 0.57 to 1.46; low certainty evidence), but suggested that ointment may lower mortality slightly (RR 0.82, 95% CI 0.68 to 0.98; RD -0.12, 95% CI -0.23 to -0.01; number needed to treat for an additional beneficial outcome 8, 95% CI 4 to 100; low certainty evidence). One trial (64 infants) that assessed the effect of coconut oil versus mineral oil in preterm infants with birth weight 1500 g to 2000 g in India reported no episodes of invasive infection or death in either group (very low certainty evidence).

Authors' conclusions: The level of certainty about the effects of emollient therapy on invasive infection or death in preterm infants is low. Since these interventions are mostly inexpensive, readily accessible, and generally acceptable, further good-quality randomised controlled trials in healthcare facilities, and in community settings in low- or middle-income countries, may be justified.

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Conflict of interest statement

None.

Figures

1
1
Study flow diagram: 2021 review update
2
2
Risk of bias summary: review authors' judgements about each risk of bias item for each included study
3
3
Forest plot of comparison: 1 Topical ointment or cream versus routine skin care, outcome: 1.1 Invasive infection (any organism).
4
4
Forest plot of comparison: 1 Topical ointment or cream versus routine skin care, outcome: 1.6 Mortality.
5
5
Forest plot of comparison: 2 Topical oil versus routine skin care, outcome: 2.1 Invasive infection (any organism).
6
6
Forest plot of comparison: 2 Topical oil versus routine skin care, outcome: 2.5 Mortality.
1.1
1.1. Analysis
Comparison 1: Topical ointment or cream versus routine skin care, Outcome 1: Invasive infection (any organism)
1.2
1.2. Analysis
Comparison 1: Topical ointment or cream versus routine skin care, Outcome 2: Invasive infection (trials with only very preterm infants participating)
1.3
1.3. Analysis
Comparison 1: Topical ointment or cream versus routine skin care, Outcome 3: Invasive infection (coagulase negative staphylococci)
1.4
1.4. Analysis
Comparison 1: Topical ointment or cream versus routine skin care, Outcome 4: Invasive infection (other bacteria)
1.5
1.5. Analysis
Comparison 1: Topical ointment or cream versus routine skin care, Outcome 5: Invasive infection (fungi)
1.6
1.6. Analysis
Comparison 1: Topical ointment or cream versus routine skin care, Outcome 6: Mortality
1.7
1.7. Analysis
Comparison 1: Topical ointment or cream versus routine skin care, Outcome 7: Mortality (trials with only very preterm infants participating)
1.8
1.8. Analysis
Comparison 1: Topical ointment or cream versus routine skin care, Outcome 8: BPD
1.9
1.9. Analysis
Comparison 1: Topical ointment or cream versus routine skin care, Outcome 9: NEC
1.10
1.10. Analysis
Comparison 1: Topical ointment or cream versus routine skin care, Outcome 10: ROP (severe)
2.1
2.1. Analysis
Comparison 2: Topical oil versus routine skin care, Outcome 1: Invasive infection (any organism)
2.2
2.2. Analysis
Comparison 2: Topical oil versus routine skin care, Outcome 2: Invasive infection (coagulase negative staphylococci)
2.3
2.3. Analysis
Comparison 2: Topical oil versus routine skin care, Outcome 3: Invasive infection (other bacteria)
2.4
2.4. Analysis
Comparison 2: Topical oil versus routine skin care, Outcome 4: Invasive infection (fungi)
2.5
2.5. Analysis
Comparison 2: Topical oil versus routine skin care, Outcome 5: Mortality
2.6
2.6. Analysis
Comparison 2: Topical oil versus routine skin care, Outcome 6: Growth
2.7
2.7. Analysis
Comparison 2: Topical oil versus routine skin care, Outcome 7: Moderate‐severe neurodevelopmental delay
2.8
2.8. Analysis
Comparison 2: Topical oil versus routine skin care, Outcome 8: BPD
2.9
2.9. Analysis
Comparison 2: Topical oil versus routine skin care, Outcome 9: NEC
2.10
2.10. Analysis
Comparison 2: Topical oil versus routine skin care, Outcome 10: ROP (severe)
2.11
2.11. Analysis
Comparison 2: Topical oil versus routine skin care, Outcome 11: Severe neurodevelopmental disability
3.1
3.1. Analysis
Comparison 3: Topical ointment or cream vs. topical oil., Outcome 1: Invasive infection (any organism)
3.2
3.2. Analysis
Comparison 3: Topical ointment or cream vs. topical oil., Outcome 2: Invasive infection (coagulase negative staphylococci)
3.3
3.3. Analysis
Comparison 3: Topical ointment or cream vs. topical oil., Outcome 3: Invasive infection (other bacteria)
3.4
3.4. Analysis
Comparison 3: Topical ointment or cream vs. topical oil., Outcome 4: Invasive infection (fungi)
3.5
3.5. Analysis
Comparison 3: Topical ointment or cream vs. topical oil., Outcome 5: Mortality
4.1
4.1. Analysis
Comparison 4: One topical oil (or combination) vs. another oil (or combination), Outcome 1: Invasive infection
4.2
4.2. Analysis
Comparison 4: One topical oil (or combination) vs. another oil (or combination), Outcome 2: Mortality
4.3
4.3. Analysis
Comparison 4: One topical oil (or combination) vs. another oil (or combination), Outcome 3: Growth
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References to other published versions of this review

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