Comment
doi: 10.1016/j.molcel.2021.04.003.
When cells are down on their LUC7L2, alternative splicing rewires metabolism for OXPHOS
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- PMID: 33961773
- DOI: 10.1016/j.molcel.2021.04.003
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Comment
When cells are down on their LUC7L2, alternative splicing rewires metabolism for OXPHOS
Mol Cell.
.
Free article
Abstract
Daniels et al. (2021) and Jourdain et al. (2021) identify LUC7L2 as a component of the U1 snRNP capable of reprogramming cellular metabolism through changes in alternative pre-mRNA splicing.
Copyright © 2021 Elsevier Inc. All rights reserved.
Comment on
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Functional analyses of human LUC7-like proteins involved in splicing regulation and myeloid neoplasms.Cell Rep. 2021 Apr 13;35(2):108989. doi: 10.1016/j.celrep.2021.108989. Cell Rep. 2021. PMID: 33852859 Free PMC article.
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Loss of LUC7L2 and U1 snRNP subunits shifts energy metabolism from glycolysis to OXPHOS.Mol Cell. 2021 May 6;81(9):1905-1919.e12. doi: 10.1016/j.molcel.2021.02.033. Epub 2021 Apr 13. Mol Cell. 2021. PMID: 33852893 Free PMC article.
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