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Comment
. 2021 May 6;81(9):1861-1862.
doi: 10.1016/j.molcel.2021.04.016.

SLiMs in intrinsically disordered protein regions regulate the cell cycle dynamics of ORC1-CDC6 interaction and pre-replicative complex assembly

Ilona Faustova  1 , Mart Loog  2
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Comment

SLiMs in intrinsically disordered protein regions regulate the cell cycle dynamics of ORC1-CDC6 interaction and pre-replicative complex assembly

Ilona Faustova et al. Mol Cell. .
Free article

Abstract

Hossain et al. (2021) show that human origin recognition complex subunit ORC1 and licensing factor CDC6 interact when the pre-replicative complex forms in G1. Short linear motifs (SLiMs) in intrinsically disordered regions (IDRs) mediate this interaction and its regulation by CDKs.

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