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Comment
. 2021 May 6;81(9):1863-1865.
doi: 10.1016/j.molcel.2021.04.005.

RNA reports breaking news from mitochondria

Nimesha Tadepalle  1 , Gerald S Shadel  2
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Free article
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RNA reports breaking news from mitochondria

Nimesha Tadepalle et al. Mol Cell. .
Free article

Abstract

Using mitochondria-targeted TALENS and ionizing radiation, consequences of mtDNA double-strand (ds) breaks were investigated by Tigano et al. (2021) who uncovered mtRNA as a retrograde second messenger of this form of mtDNA stress that activates the RIG-I/MAVS innate immune signaling pathway.

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