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. 2021 May 6;81(9):1866-1867.
doi: 10.1016/j.molcel.2021.04.017.

ecDNA party bus: Bringing the enhancer to you

Karen Adelman  1 , Benjamin J E Martin  2
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ecDNA party bus: Bringing the enhancer to you

Karen Adelman et al. Mol Cell. .
Free article

Abstract

Recent work from Zhu et al. (2021) reveals that extrachromosomal DNA circles harboring enhancers can serve as mobile regulatory elements that interact with chromosomal oncogenes, stimulating high-level gene activity and contributing to tumor heterogeneity and cancer progression.

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