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. 1988 Mar;6(1):23-8.

A study of HLA class II antigens in an Italian paediatric population with coeliac disease

M Morellini  1 , S Trabace, M C Mazzilli, P Lulli, S Cappellacci, M Bonamico, I Margarit, E Gandini
Affiliations
  • PMID: 3396269

A study of HLA class II antigens in an Italian paediatric population with coeliac disease

M Morellini et al. Dis Markers. 1988 Mar.

Abstract

One hundred and twenty-one Italian children with coeliac disease (CD) have been compared with a control population from the same geographical area for the distribution of HLA-DR and DQ antigens. The pattern of an increase in DR3, DR7, and of heterozygotes DR5/7 was associated with an excess of heterozygotes DQw2/DQw3 in the CD population. These findings suggest that epitopes determined by specific combinations of DQ alpha and beta chains (combinatorial determinants) predispose to the disease.

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