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. 2021 Sep 1;149(5):1044-1053.
doi: 10.1002/ijc.33673. Epub 2021 May 17.

International trends in incidence of osteosarcoma (1988-2012)

Gabriela A Rojas  1 , Aubrey K Hubbard  2 , Brandon J Diessner  2 , Karina B Ribeiro  1 , Logan G Spector  2   3
Affiliations

International trends in incidence of osteosarcoma (1988-2012)

Gabriela A Rojas et al. Int J Cancer. .

Abstract

Osteosarcoma (OS) is the most common primary bone tumor in children and adolescents. The etiology of OS is largely unknown but may be informed by comparisons of incidence and trends between geographic regions. Using the Cancer Incidence in Five Continents (CI5) data from 1988 to 2012, we present OS age-standardized incidence rates (ASRs; cases/million) and average annual percent change (AAPC) and 95% confidence interval (CI) by geographic region among the age groups 0-9, 10-19, 20-29, 30-59, 60-79, 0-79. Among the 10-19 age group, we also used the most recent data (2008-2012) to present the ASRs for each country. We observed little variation in OS incidence between geographic regions in 2008-2012 across all age groups. Overall, the ASR for 0-79 ranged from 2 cases per million in Southern Asia to 4.2 in Sub-Saharan Africa. A bimodal distribution in incidence was observed with peaks in the 10-19 and 60-79 age groups across all regions over time. Overall, OS incidence was relatively stable across 1988-2012 with the only statistically significant increases in the 0-79 age group observed in Eastern Asia (AAPC: 1.8; 95% CI: 0.6, 1.9) and Sub-Saharan Africa (AAPC: 3.1; 95% CI: 0.5, 5.8). The small variation in incidence between regions and the stability in incidence over time suggests that OS carcinogenesis is not influenced by environmental or time-varying exposures.

Keywords: bone cancer; epidemiology; incidence; international; osteosarcoma.

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Conflict of interest statement

Conflict of Interest

The authors have no conflict of interest relevant to this article to disclose.

Figures

Figure 1:
Figure 1:
Osteosarcoma (OS) age standardized incidence rates (ASR) and 95% confidence intervals (CI) by age group, sex, and geographic region using the Cancer Incidence in Five Continents (CI5) data (2008–2012).
Figure 2:
Figure 2:
Osteosarcoma (OS) age standardized incidence rates (ASR) per country in the 10–19-year-old age category in the Cancer Incidence in Five Continents (CI5) in 2008–2012.
Figure 3:
Figure 3:
Overall average annual percent change (AAPC) and 95% confidence interval (CI) in each geographic region for males and females using the Cancer Incidence in Five Continents (CI5) data from 1988 to 2012.
Figure 4:
Figure 4:
Average annual percent change (AAPC) and 95% confidence interval (CI) in by geographic region in each age group using the Cancer Incidence in Five Continents (CI5) data from 1988 to 2012. *AAPCs were not calculated when there were less than 5 cases in three or more time-periods.
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