Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2021 May 8;23(7):9.
doi: 10.1007/s11894-021-00811-8.

B Cell Lymphomas of the GI Tract

Sara Small  1 , Liron Barnea Slonim  2 , Corinne Williams  3 , Reem Karmali  4   5
Affiliations
Review

B Cell Lymphomas of the GI Tract

Sara Small et al. Curr Gastroenterol Rep. .

Abstract

Purpose of the review: Primary GI lymphomas of B cell origin are a diverse group of lymphomas. In this article, we provide an overview of the diagnosis, pathologic and molecular features, and management of these varied lymphomas.

Recent findings: The most common primary GI lymphomas are diffuse large B cell lymphoma (DLBCL) and marginal zone lymphomas (MZL), but follicular lymphomas (FL), mantle cell lymphomas (MCL), post-transplant lymphoproliferative disorders (PTLD), and Burkitt lymphoma of the GI tract also occur. Many features of these lymphomas are similar to their nodal counterparts, but certain clinical and biological aspects are unique. Diagnostic and treatment strategies for these lymphomas continue to evolve over time. There are ongoing discoveries about the unique pathophysiology, molecular characteristics, and complications of primary B cell GI lymphomas that are already leading to improvements in management of this histologically diverse set of lymphomas.

Keywords: GI lymphomas; Gastric lymphoma; Intestinal lymphoma.

PubMed Disclaimer

References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance
    1. Surveillance, Epidemiology, and End Results (SEER) Program ( www.seer.cancer.gov ) SEER*Stat Database: Mortality - All COD, Aggregated With State, Total U.S. (1969–2017). National Cancer Institute, DCCPS, Surveillance Research Program, released December 2019 Underlying mortality data provided by NCHS (wwwcdcgov/nchs).
    1. Bautista-Quach MA, Ake CD, Chen M, Wang J. Gastrointestinal lymphomas: morphology, immunophenotype and molecular features. J Gastrointest Oncol. 2012;3(3):209–25. - PubMed - PMC
    1. Shuji Yamamoto HN, Yamashita K, Matsuura M, Takada M, Kawanami C, Chiba T. Gastrointestinal follicular lymphoma: review of the literature. J Gastroenterol. 2010;45:370–88. - DOI
    1. Takata K, Miyata-Takata T, Sato Y, Iwamuro M, Okada H, Tari A, et al. Gastrointestinal follicular lymphoma: current knowledge and future challenges. Pathol Int. 2018;68(1):1–6 Review that differentiates between nodal FL and GI-FL. - DOI
    1. Takata K, Tanino M, Ennishi D, Tari A, Sato Y, Okada H, et al. Duodenal follicular lymphoma: comprehensive gene expression analysis with insights into pathogenesis. Cancer Sci. 2014;105(5):608–15.

MeSH terms

LinkOut - more resources