Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2021 Aug;100(2):457-458.
doi: 10.1016/j.kint.2021.04.033. Epub 2021 May 5.

Minimal change disease relapse following SARS-CoV-2 mRNA vaccine

Delphine Kervella  1 , Lola Jacquemont  2 , Agnès Chapelet-Debout  2 , Clément Deltombe  2 , Simon Ville  3
Affiliations
Case Reports

Minimal change disease relapse following SARS-CoV-2 mRNA vaccine

Delphine Kervella et al. Kidney Int. 2021 Aug.
No abstract available

PubMed Disclaimer

Figures

Figure 1
Figure 1
Urine protein-to-creatinine ratio and steroid dose during follow-up. (1) Diagnosis of idiopathic nephrotic syndrome (iNS; minimal change disease diagnosed on kidney biopsy). (2) First relapse when tapering steroids from 10 mg to 9 mg; increase of steroid dose to 1 mg/kg (60 mg), leading to remission of NS. (3) Second relapse when tapering steroids from 12.5 mg to 10 mg; increase of steroid dose to 0.5 mg/kg, leading to remission. Coronavirus disease 2019 (COVID-19) mRNA vaccine was injected while the patient was treated with 0.4 mg/kg steroids (25 mg; ongoing tapering from last relapse occurring 6 weeks before first vaccine injection; no proteinuria on urine dipstick test at the time of vaccine injection). (4) Proteinuria after first mRNA COVID-19 vaccine injection; increase of steroid dose from 25 mg to 30 mg (0.5 mg/kg). (5) Proteinuria increase after second mRNA COVID-19 vaccine injection; increase of steroids to 60 mg (1 mg/kg), leading to remission.
See this image and copyright information in PMC

Comment in

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Vivarelli M., Massella L., Ruggiero B., Emma F. Minimal change disease. Clin J Am Soc Nephrol. 2017;12:332–345. - PMC - PubMed
    1. Patel C., Shah H.H. Vaccine-associated kidney diseases: a narrative review of the literature. Saudi J Kidney Dis Transpl. 2019;30:1002. - PubMed
    1. Abeyagunawardena A., Goldblatt D., Andrews N., Trompeter R. Risk of relapse after meningococcal C conjugate vaccine in nephrotic syndrome. Lancet. 2003;362:449–450. - PubMed