Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Jun:52:101959.
doi: 10.1016/j.ejon.2021.101959. Epub 2021 Apr 28.

Development of a patient-reported outcome tool for assessing symptom burden during perioperative care in liver surgery: The MDASI-PeriOp-Hep

Xin Shelley Wang  1 , Qiuling Shi  2 , Loretta A Williams  2 , Heather A Lillemoe  3 , Ting-Yu Chen  2 , Vijaya Gottumukkala  4 , Araceli Garcia-Gonzalez  2 , Donna Malveaux  2 , Mona Kamal  5 , Charles S Cleeland  2 , Thomas A Aloia  6
Affiliations

Development of a patient-reported outcome tool for assessing symptom burden during perioperative care in liver surgery: The MDASI-PeriOp-Hep

Xin Shelley Wang et al. Eur J Oncol Nurs. 2021 Jun.

Abstract

Purpose: Based on the MD Anderson Symptom Inventory (MDASI), we developed a Patient-reported outcomes tool for hepatectomy perioperative care (MDASI-PeriOp-Hep).

Methods: To establish the content validity, we generated PeriOp-Hep-specific candidate items from qualitative interviews of patients (n = 30), and removed items that lacked clinical relevance on the basis of input from panels of patients, caregivers, and clinicians. The psychometric properties of the MDASI-PeriOp-Hep were validated (n = 150). The cognitive debriefing and clinical interpretability were assessed to confirm the ease of comprehension, relevance, and acceptability of the tool.

Results: Five symptoms specific to hepatectomy (abdominal bloating, tightness, or fullness; abdominal cramping; muscle weakness, instability, or vertigo; constipation; and incisional tightness) were identified as module items to form the MDASI-PeriOp-Hep. The Cronbach αs for symptoms and for interference were 0.898 and 0.861, respectively. The test-retest reliability was 0.887 for all 18 symptom severity items. Compared to other commonly used tools, correlation of MDASI-PeriOp-Hep scores to performance status (all, P < 0.001) and to the phase of perioperative care confirmed known-group validity. Convergent validity was excellent against other standard Patient-reported outcomes tools. Cognitive debriefing demonstrated that the MDASI-PeriOp-Hep was an easy to use and understandable tool.

Conclusions: For integrating patient-reported outcomes in perioperative patient care, a procedure-specific tool is desirable. The MDASI-PeriOp-Hep is a valid, reliable, concise tool for measuring symptom severity and functional interference in patients undergoing liver surgery.

Keywords: Cancer; Functional recovery; Liver surgery; MDASI; Patient-reported outcome; Perioperative care; Symptom burden; Validation.

PubMed Disclaimer

Conflict of interest statement

Conflicts Of Interest: The MD Anderson Symptom Inventory and its derivative versions are copyrighted and licensed by The University of Texas MD Anderson Cancer Center and Charles S. Cleeland. Xin Shelley Wang and Charles S. Cleeland have a financial interest in the MDASI and its derivative versions. The authors report no other conflicts of interest.

References

    1. Aahlin EK, von Meyenfeldt M, Dejong CH, Ljungqvist O, Fearon KC, Lobo DN, Demartines N, Revhaug A, Wigmore SJ, Lassen K, 2014. Functional recovery is considered the most important target: a survey of dedicated professionals. Perioper Med (Lond) 3, 5–5. - PMC - PubMed
    1. Akoglu H, 2018. User’s guide to correlation coefficients. Turk J Emerg Med 18, 91–93. - PMC - PubMed
    1. Barsevick AM, Whitmer K, Nail LM, Beck SL, Dudley WN, 2006. Symptom cluster research: conceptual, design, measurement, and analysis issues. J. Pain Symptom Manage 31, 85–95. - PubMed
    1. Blazeby JM, Fayers P, Conroy T, Sezer O, Ramage J, Rees M, 2009. Validation of the European Organization for Research and Treatment of Cancer QLQ-LMC21 questionnaire for assessment of patient-reported outcomes during treatment of colorectal liver metastases. Br. J. Surg 96, 291–298. - PubMed
    1. Cella D, Butt Z, Kindler HL, Fuchs CS, Bray S, Barlev A, Oglesby A, 2013. Validity of the FACT Hepatobiliary (FACT-Hep) questionnaire for assessing disease-related symptoms and health-related quality of life in patients with metastatic pancreatic cancer. Qual. Life Res 22, 1105–1112. - PubMed