Comment
doi: 10.1016/j.tins.2021.04.002.
Epub 2021 May 6.
Stopping the Clock on Seizures!
Affiliations
- PMID: 33965214
- DOI: 10.1016/j.tins.2021.04.002
Item in Clipboard
Comment
Stopping the Clock on Seizures!
Trends Neurosci.
2021 Jun.
Abstract
A recent paper by Zhang et al. shows that REV-ERBα, a negative regulator of the circadian molecular clock, is pro-convulsant through its action on GABA signaling. The findings support the role of the circadian molecular clock in epilepsy and suggest REV-ERBα as a potential therapeutic target for the management of seizures.
Keywords: circadian molecular clock; epilepsy; tonic GABA.
Copyright © 2021 Elsevier Ltd. All rights reserved.
Conflict of interest statement
Declaration of Interests The authors declare no competing interests in relation to this work.
Comment on
-
Dysregulation of REV-ERBα impairs GABAergic function and promotes epileptic seizures in preclinical models.Nat Commun. 2021 Feb 22;12(1):1216. doi: 10.1038/s41467-021-21477-w. Nat Commun. 2021. PMID: 33619249 Free PMC article.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
