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. 2020 Apr 23:S0040-5957(20)30068-8.
doi: 10.1016/j.therap.2020.04.004. Online ahead of print.

[Diabetes and COVID-19]

[Article in French]
Béatrice Bouhanick  1 , Jean-Luc Cracowski  2 , Jean-Luc Faillie  3 ; groupe de travail "médicaments et COVID-19" de la Société française de pharmacologie et thérapeutique
Affiliations

[Diabetes and COVID-19]

[Article in French]
Béatrice Bouhanick et al. Therapie. .

Abstract
in English, French

According to previous reports, diabetes seems to be associated with serious clinical events due to COVID-19. But is diabetes per se a risk factor of being infected by the virus? We discuss these points. Data about the antidiabetic drugs are scarce. Dipeptidylpeptidase-4 (DPP-4) is found as both a cell surface protein ubiquitously expressed in many tissues and as a soluble molecule found in serum/plasma, fluids. DPP-4 is involved in infection of cells by some viruses. We relate data about the use of DPP-4 inhibitors in diabetic patients. We conclude relating French and international recommendations in people with diabetes.

D’après les dernières analyses de cas notamment en Chine et en Italie, le diabète semble être un facteur de risque d’aggravation de l’état clinique d’un patient atteint par le COVID-19 mais est-il un facteur de susceptibilité ? Une analyse de la littérature à la date du 17 avril 2020 tente de répondre à la question. Les données concernant le type de traitement antidiabétique sont très rares. La dipeptidylpeptidase-4 (DPP-4), glycoprotéine membranaire ubiquitaire présente à la surface de nombreuses cellules et existant aussi sous forme soluble, est impliquée dans les réponses immunitaires inflammatoires en modifiant la production de plusieurs cytokines. La DPP-4 est impliquée dans l’infection des cellules par certains virus. Nous abordons la question de l’utilisation des inhibiteurs des DPP-4 chez les patients diabétiques. Une revue des recommandations sur la prise en charge des diabétiques conclut ce travail.

Keywords: COVID-19; DPP-4 inhibitors; Diabetes; Diabète; Epidemiology; Inhibiteurs des DPP-4; Recommandations; Recommendations; Épidémiologie.

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