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. 2022 Apr;86(4):934-936.
doi: 10.1016/j.jaad.2021.03.066. Epub 2021 May 5.

Combined reflectance confocal microscopy and optical coherence tomography to improve the diagnosis of equivocal lesions for basal cell carcinoma

Jilliana Monnier  1 , Nathalie De Carvalho  2 , Ucalene Harris  3 , Jason Garfinkel  4 , Aleissa Saud  5 , Cristian Navarrete-Dechent  6 , Konstantinos Liopyris  7 , Ofer Reiter  8 , Gennady Rubinstien  4 , Nicusor Iftimia  9 , Kishwer S Nehal  3 , Alina Markova  3 , Liang Deng  3 , Anthony M Rossi  3 , Ashfaq A Marghoob  3 , Michael A Marchetti  3 , Veronica Rotemberg  3 , Giovanni Pellacani  2 , Manu Jain  10
Affiliations

Combined reflectance confocal microscopy and optical coherence tomography to improve the diagnosis of equivocal lesions for basal cell carcinoma

Jilliana Monnier et al. J Am Acad Dermatol. 2022 Apr.
No abstract available

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Conflict of interest statement

Conflicts of interest Jain received one time travel re-imbursement in past by Caliber ID for a scientific congress. Iftimia works at Physical Sciences, Inc. However, the company does not have any financial interest, as this is research instrument, and its development was funded by NIH. Authors Monnier, De Carvalho, Harris, Garfinkel, Saud, Navarrete-Dechent, Liopyris, Reiter, Rubinstien, Nehal, Markova, Deng, Rossi, Marghoob, Marchetti, Rotemberg, and Pellacani have no conflicts of interest to declare.

Figures

Figure 1 (A) and Figure 2 (B):
Figure 1 (A) and Figure 2 (B):
Images of a small 2 mm non-pigmented equivocal papule, featureless on dermoscopy (inset A, circled area), acquired with an RCM hand-held device (A) and an RCM-OCT device (B). (A) RCM image shows a dark silhouette at the level of epidermis/ dermo-epidermal junction (yellow asterisks). In the absence of a definitive BCC tumor nodule with palisading and clefting a diagnosis of BCC with moderate confidence was made with RCM- alone. (B) OCT image acquired with the RCM-OCT device shows a grey nodule connected to the epidermis with clefting (yellow arrow) and compressed collagen compressed bundle (purple asterisks). The BCC tumor nodule measured 220 μm in depth on OCT. Combined RCM-OCT increased the diagnostic confidence for BCC over RCM-alone which led to the direct excision of the lesion. The lesion showed a superficial BCC on histopathology (inset B). FOV: RCM image= 0.75mm x 0.75mm; OCT image= 2 mmx 1mm; H&E image: 10x magnification.
See this image and copyright information in PMC

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References

    1. Kadouch DJ, Leeflang MM, Elshot YS, Longo C, Ulrich M, van der Wal AC, et al. Diagnostic accuracy of confocal microscopy imaging vs. punch biopsy for diagnosing and subtyping basal cell carcinoma. J Eur Acad Dermatol Venereol oct 2017;31(10):1641–8. - PMC - PubMed
    1. Jain M, Pulijal SV, Rajadhyaksha M, Halpern AC, Gonzalez S. Evaluation of Bedside Diagnostic Accuracy, Learning Curve, and Challenges for a Novice Reflectance Confocal Microscopy Reader for Skin Cancer Detection In Vivo. JAMA Dermatol January 2018;154(8):962–5. - PMC - PubMed
    1. Iftimia N, Yélamos O, Chen C-SJ, Maguluri G, Cordova MA, Sahu A, et al. Handheld optical coherence tomography–reflectance confocal microscopy probe for detection of basal cell carcinoma and delineation of margins. JBO. juill 2017;22(7):076006. - PMC - PubMed
    1. Sahu A, Yélamos O, Iftimia N, Cordova M, Alessi-Fox C, Gill M, et al. Evaluation of a Combined Reflectance Confocal Microscopy-Optical Coherence Tomography Device for Detection and Depth Assessment of Basal Cell Carcinoma. JAMA Dermatol January 2018;154(10):1175–83. - PMC - PubMed
    1. Holmes J, Braunmühl T von, Berking C, Sattler E, Ulrich M, Reinhold U, et al. Optical coherence tomography of basal cell carcinoma: influence of location, subtype, observer variability and image quality on diagnostic performance. British Journal of Dermatology 2018;178(5):1102–10. - PubMed

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