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. 2022 Apr;86(4):934-936.
doi: 10.1016/j.jaad.2021.03.066. Epub 2021 May 5.

Combined reflectance confocal microscopy and optical coherence tomography to improve the diagnosis of equivocal lesions for basal cell carcinoma

Jilliana Monnier  1 , Nathalie De Carvalho  2 , Ucalene Harris  3 , Jason Garfinkel  4 , Aleissa Saud  5 , Cristian Navarrete-Dechent  6 , Konstantinos Liopyris  7 , Ofer Reiter  8 , Gennady Rubinstien  4 , Nicusor Iftimia  9 , Kishwer S Nehal  3 , Alina Markova  3 , Liang Deng  3 , Anthony M Rossi  3 , Ashfaq A Marghoob  3 , Michael A Marchetti  3 , Veronica Rotemberg  3 , Giovanni Pellacani  2 , Manu Jain  10
Affiliations

Combined reflectance confocal microscopy and optical coherence tomography to improve the diagnosis of equivocal lesions for basal cell carcinoma

Jilliana Monnier et al. J Am Acad Dermatol. 2022 Apr.
No abstract available

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Conflict of interest statement

Conflicts of interest Jain received one time travel re-imbursement in past by Caliber ID for a scientific congress. Iftimia works at Physical Sciences, Inc. However, the company does not have any financial interest, as this is research instrument, and its development was funded by NIH. Authors Monnier, De Carvalho, Harris, Garfinkel, Saud, Navarrete-Dechent, Liopyris, Reiter, Rubinstien, Nehal, Markova, Deng, Rossi, Marghoob, Marchetti, Rotemberg, and Pellacani have no conflicts of interest to declare.

Figures

Figure 1 (A) and Figure 2 (B):
Figure 1 (A) and Figure 2 (B):
Images of a small 2 mm non-pigmented equivocal papule, featureless on dermoscopy (inset A, circled area), acquired with an RCM hand-held device (A) and an RCM-OCT device (B). (A) RCM image shows a dark silhouette at the level of epidermis/ dermo-epidermal junction (yellow asterisks). In the absence of a definitive BCC tumor nodule with palisading and clefting a diagnosis of BCC with moderate confidence was made with RCM- alone. (B) OCT image acquired with the RCM-OCT device shows a grey nodule connected to the epidermis with clefting (yellow arrow) and compressed collagen compressed bundle (purple asterisks). The BCC tumor nodule measured 220 μm in depth on OCT. Combined RCM-OCT increased the diagnostic confidence for BCC over RCM-alone which led to the direct excision of the lesion. The lesion showed a superficial BCC on histopathology (inset B). FOV: RCM image= 0.75mm x 0.75mm; OCT image= 2 mmx 1mm; H&E image: 10x magnification.
See this image and copyright information in PMC

References

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